4,4-DIPHENYL-3-BUTENOIC ACID

Base Information

• Chemical Name: 4,4-DIPHENYL-3-BUTENOIC ACID
• CAS No.: 7498-88-6
• Molecular Formula: C16H14O2
• Molecular Weight: 238.286
• Hs Code.: 2916399090
• Mol file: 7498-88-6.mol

Synonyms:4,4-Diphenyl-but-3-ensaeure;1.1-Diphenyl-propen-(1)-carbonsaeure-(3);3-Butenoic acid,4-diphenyl;4,4-diphenyl-but-3-enoic acid;3-Butenoic acid,4,4-diphenyl;4,4-Diphenyl-3-butenoic acid;

Chemical Property of 4,4-DIPHENYL-3-BUTENOIC ACID

Chemical Property:

• Vapor Pressure: 5.26E-07mmHg at 25°C
• Boiling Point: 396.7°Cat760mmHg
• Flash Point: 293.5°C
• PSA: 37.30000
• Density: 1.145g/cm³
• LogP: 3.59300

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,4-DIPHENYL-BUT-3-ENOIC ACID AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4-DIPHENYL-3-BUTENOIC ACID

There total 31 articles about 4,4-DIPHENYL-3-BUTENOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

formic acid (64-18-6) + 3,3-diphenylprop-2-en-1-ol (4801-14-3) → 4,4-diphenylbut-3-enoic acid (7498-88-6)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; acetic anhydride; nixantphos; In toluene; at 100 ℃; for 20h; Inert atmosphere; Schlenk technique; Green chemistry;

Reference yield: 75.0%

Diphenylacetaldehyde (947-91-1) + malonic acid (141-82-2) → 4,4-diphenylbut-3-enoic acid (7498-88-6)

Guidance literature:

With piperidine; at 85 ℃; for 3h;

DOI:10.1016/j.bmc.2006.09.010

Reference yield: 70.0%

bromobenzene (108-86-1,52753-63-6) + trans-styrylacetic acid (2243-53-0,59744-46-6,1914-58-5) → 4,4-diphenylbut-3-enoic acid (7498-88-6)

Guidance literature:

With palladium diacetate; sodium hexamethyldisilazane; nixantphos; In toluene; at 80 ℃; for 12h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol503545j

upstream raw materials:

1,1-diphenyl-1-propene

cumyl potassium

Diphenylacetaldehyde

malonic acid

Downstream raw materials:

4-phenyl-1-naphthol

5,5-diphenyl-3-(1,1-diphenylmethyl)-4-penten-2-one

Methyl 4,4-diphenyl-3-butenoate

methyl 2-(2,2-diphenylcyclopropyl)acetate

Refernces

• 1、 Fu, Ming-Chen,Shang, Rui,Cheng, Wan-Min,Fu, Yao. "Efficient Pd-Catalyzed Regio- and Stereoselective Carboxylation of Allylic Alcohols with Formic Acid". . p. 8818 - 8822. Retrieved 2017/07/11.
• 2、 Moragas, Toni,Martin, Ruben. "Nickel-Catalyzed Reductive Carboxylation of Cyclopropyl Motifs with Carbon Dioxide". . p. 2816 - 2822. Retrieved 2016/08/26.