2-Methylpentanamide

Base Information

• Chemical Name: 2-Methylpentanamide
• CAS No.: 6941-49-7
• Molecular Formula: C6H13 N O
• Molecular Weight: 115.175
• Hs Code.: 2924199090
• NSC Number: 38213
• ChEMBL ID: CHEMBL1075734
• Mol file: 6941-49-7.mol

Synonyms:2-methylvaleramide

Chemical Property of 2-Methylpentanamide

Chemical Property:

• Vapor Pressure: 0.0291mmHg at 25°C
• Boiling Point: 245.2°C at 760 mmHg
• Flash Point: 102.1°C
• PSA: 43.09000
• Density: 0.894g/cm³
• LogP: 1.60820
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 115.099714038
• Heavy Atom Count: 8
• Complexity: 80.6

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC(C)C(=O)N

Technology Process of 2-Methylpentanamide

There total 8 articles about 2-Methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-methylvaleraldehyde (123-15-9) → 2-methylpentanamide (6941-49-7)

Guidance literature:

2-methylvaleraldehyde; With hydroxylamine hydrochloride; In dimethyl sulfoxide; at 100 ℃;

With water; dihydrogen peroxide; sodium hydroxide; In dimethyl sulfoxide;

DOI:10.1080/00397910903219443

Reference yield:

1-penten (109-67-1) + carbon monoxide (201230-82-2) → Caproamide (628-02-4) + 2-methylpentanamide (6941-49-7)

Guidance literature:

With ammonium chloride; In 1-methyl-pyrrolidin-2-one; at 129.84 ℃; for 24h; under 22502.3 Torr; Overall yield = 51percent; Catalytic behavior;

DOI:10.1016/j.apcata.2021.118026

Reference yield:

2-methylvaleryl chloride (116908-84-0,5238-27-7) → 2-methylpentanamide (6941-49-7)

Guidance literature:

With ammonia; water;

upstream raw materials:

ethyl 3-methylpentanoate

2-methyl-Pentanenitrile

2-methylvaleryl chloride

2-Methylpentanoic acid

Downstream raw materials:

2-methyl-Pentanenitrile

2-methylpentylamine

Refernces

• 1、 Hu, Qu-Ping,Cheng, Jing,Wang, Ying,Shi, Jie,Wang, Bi-Qin,Hu, Ping,Zhao, Ke-Qing,Pan, Fei. "Remote Regioselective Radical C-H Functionalization of Unactivated C-H Bonds in Amides: The Synthesis of gem-Difluoroalkenes". supporting information. p. 4457 - 4462. Retrieved 2021/05/26.
• 2、 Sun, Zhao,Yan, Li,Ji, Guangjun,Wang, Guoqing,Ma, Lei,Jiang, Miao,Li, Cunyao,Ding, Yunjie. "Efficient heterogeneous hydroaminocarbonylation of olefins with ammonium chloride as amino source". . . Retrieved 2021/02/26.