2-chloro-N-methylethanamine hydrochloride

Base Information

• Chemical Name: 2-chloro-N-methylethanamine hydrochloride
• CAS No.: 4535-90-4
• Molecular Formula: C3H8 Cl N . Cl H
• Molecular Weight: 130.017
• Hs Code.: 2921199090
• European Community (EC) Number: 224-882-3
• DSSTox Substance ID: DTXSID80884087
• Mol file: 4535-90-4.mol

Synonyms:4535-90-4;2-chloro-N-methylethanamine hydrochloride;2-Methylaminoethyl chloride HCl;2-methylaminoethyl chloride hydrochloride;Ethanamine, 2-chloro-N-methyl-, hydrochloride;(2-CHLOROETHYL)(METHYL)AMINE HYDROCHLORIDE;MFCD00050517;(2-chloroethyl)methylamine hydrochloride;2-Chloro-N-methylethanamine HCl;Ethanamine, 2-chloro-N-methyl-, hydrochloride (1:1);C3H8ClN.ClH;N-Methyl-2-chloroethylamine Hydrochloride;N-Methyl-beta-chloroethylamine hydrochloride;C3H9Cl2N;SCHEMBL39861;NIOSH/KH1392500;DTXSID80884087;FGSHJLJPYBUBHO-UHFFFAOYSA-N;2-chloroethyl-methylamine hydrochloride;AKOS016011995;2-Chloro-N-methylethamine hydrochloride;2-methylaminoethylchloride hydrochloride;CS-W019383;2-chloro-ethyl-methylamine hydrochloride;2-chloro-N-methylethanaminehydrochloride;2-chloro-N-methylethanamine;hydrochloride;AM803928;AS-17989;SY057666;2-chloro-n-methyl-ethanamine hydrochloride;2-N-Methylaminoethyl chloride hydrohloride;(2-chloro-ethyl)-methyl-amine hydrochloride;2-N-Methylaminoethyl chloride hydrochloride;Ethamine, 2-chloro-N-methyl-, hydrochloride;FT-0664656;KH13925000;EN300-83889;N-methyl-N-(2-chloroethyl)amine hydrochloride;J-500712;F2147-1522

Chemical Property of 2-chloro-N-methylethanamine hydrochloride

Chemical Property:

• Vapor Pressure: 23.8mmHg at 25°C
• Melting Point: 89 °C
• Boiling Point: 110.3°Cat760mmHg
• Flash Point: 20.5°C
• PSA: 12.03000
• Density: g/cm³
• LogP: 1.63750
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 129.0112047
• Heavy Atom Count: 6
• Complexity: 16.4

Purity/Quality:

98% ^*data from raw suppliers

2-Chloro-N-methylethanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CNCCCl.Cl
• Uses: 2-Chloro-N-Methylethanamine Hydrochloride is an aminoalkoxyimino derivative used in the preparation of amino derivatives of B-homoandrostanes and B-heteroandrostanes for the treatment of cardiovascular disorders. 2-Chloro-N-methylethanamine Hydrochloride is used in the preparation of pyrimidine derivatives and related heterocycles as CDK inhibitors for treatment of diseases.

Technology Process of 2-chloro-N-methylethanamine hydrochloride

There total 6 articles about 2-chloro-N-methylethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(2-hydroxyethyl)(methyl)amine (109-83-1) → N-methyl-2-chloroethylamine hydrochloride (4535-90-4)

Guidance literature:

With hydrogenchloride; thionyl chloride; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00014a019

Reference yield: 80.0%

2-(methylamino)ethan-1-ol hydrochloride (62640-03-3) → N-methyl-2-chloroethylamine hydrochloride (4535-90-4)

Guidance literature:

With sulfuryl dichloride; In chloroform; at 0 ℃; for 3h; Reflux;

Reference yield:

→ N-methyl-2-chloroethylamine hydrochloride (4535-90-4)

Guidance literature:

With hydrogenchloride; at 160 - 180 ℃;

upstream raw materials:

N-methylaziridine

(2-hydroxyethyl)(methyl)amine

2-(methylamino)ethan-1-ol hydrochloride

Downstream raw materials:

biphenyl-2-ylcarbamic acid 1-[2-(methylamino)ethyl]piperidin-4-yl ester

2-(diphenylphosphino)-N-methylethanamine

N-(2-(dimethylamino)ethyl)-N-(4-nitrophenyl)methanesulfonamide

C₂₂H₂₃F₂N₇O₂

Refernces

• 1、 Rayder, Thomas M.,Adillon, Enric H.,Byers, Jeffery A.,Tsung, Chia-Kuang. "A Bioinspired Multicomponent Catalytic System for Converting Carbon Dioxide into Methanol Autocatalytically". supporting information. p. 1742 - 1754. Retrieved 2020/05/25.
• 2、 Xu, Chao-Ran,Zhang, Ze,Pan, Cai-Yuan,Hong, Chun-Yan. "A strategy combining quantitative reactions and reversible-covalent chemistry for sequential synthesis of sequence-controlled polymers with different sequences". . p. 294 - 304. Retrieved 2019/04/25.