(Difluoromethyl)trimethylsilane

Base Information

• Chemical Name: (Difluoromethyl)trimethylsilane
• CAS No.: 65864-64-4
• Molecular Formula: C4H10F2Si
• Molecular Weight: 124.206
• Hs Code.: 29319090
• European Community (EC) Number: 804-145-8
• DSSTox Substance ID: DTXSID20457496
• Nikkaji Number: J1.915.207C
• Mol file: 65864-64-4.mol

Synonyms:(difluoromethyl)trimethylsilane;65864-64-4;Difluoromethyltrimethylsilane;Silane, (difluoromethyl)trimethyl-;difluoromethyl(trimethyl)silane;Difluoromethyl-trimethyl-silane;(Difluoromethyl)(trimethyl)silane;Difluoromethyl)trimethylsilane;Me3Sicf2H;trimethyl(difluoromethyl)silane;SCHEMBL4854565;(Difluoromethyl)trimethyl-silane;AMY6657;DTXSID20457496;BCP32220;BBL103460;MFCD19381658;STL557270;AKOS015913928;SB38170;AS-53422;D4364;EN300-106165;P16466;(Difluoromethyl)trimethylsilane, >=98.0% (GC);J-501802;(Difluoromethyl)trimethylsilane

Chemical Property of (Difluoromethyl)trimethylsilane

Chemical Property:

• Refractive Index: 1.3560-1.3600
• Boiling Point: 52°C(lit.)
• Flash Point: -17℃
• PSA: 0.00000
• Density: 0.877±0.06 g/cm3(Predicted)
• LogP: 2.54880
• Storage Temp.: 0-10°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 124.05198318
• Heavy Atom Count: 7
• Complexity: 55.2

Purity/Quality:

98%,99%, ^*data from raw suppliers

(Difluoromethyl)trimethylsilane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 2423974
• Hazard Codes: F
• Statements: 11
• Safety Statements: 15-7-35

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)C(F)F

Technology Process of (Difluoromethyl)trimethylsilane

There total 4 articles about (Difluoromethyl)trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloro-trimethyl-silane (75-77-4) + [chloro(difluoro)methyl]trimethylsilane (115262-00-5) → trimethylsilyl fluoride (420-56-4) + trimethyl(difluoromethyl)silane (65864-64-4) + bis(trimethylsilyl)difluoromethane (86847-53-2) + 1,2-bis(trimethylsilyl)-1,1,2,2-tetrafluoroethane (186824-44-2)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; tetrabutylammomium bromide; In tetrahydrofuran; Mechanism; Product distribution; electrolysis, Al anode, Ni cathode, other reagents: tris(3,6-dioxaheptyl)amine, tetrabutylammonium hexafluorophosphate, magnesium, various current density, various reactant ratios;

DOI:10.1021/ja962990n

Reference yield:

(difluoromethyl)silane (10112-10-4) → methyl fluorosilane (753-44-6) + methyldifluorosilane (420-34-8) + methyltrifluorosilane (373-74-0) + trimethyl(difluoromethyl)silane (65864-64-4)

Guidance literature:

at 210 - 220 ℃; for 7h; Title compound not separated from byproducts;

DOI:10.1016/0022-328X(92)80068-9

Reference yield:

benzaldehyde (100-52-7) + bis(trimethylsilyl)difluoromethane (86847-53-2) → Difluoromethane (75-10-5) + trimethyl(difluoromethyl)silane (65864-64-4) + (2,2-Difluoro-2-trimethylsilanyl-1-trimethylsilanyloxy-ethyl)-benzene

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,2-dimethoxyethane; for 24h; Mechanism; Product distribution; Ambient temperature; other aldehydes and ketones, other reagents: KF, N-methylpyrrolidinone, other solvent: THF;

DOI:10.1021/ja962990n

upstream raw materials:

(difluoromethyl)silane

chloro-trimethyl-silane

[chloro(difluoro)methyl]trimethylsilane

benzaldehyde

Downstream raw materials:

2-((4-(difluoromethyl)benzyl)oxy)tetrahydro-2H-pyran

N-(4-(difluoromethyl)phenyl)-N-methylpivalamide

N-(4-(difluoromethyl)benzyl)-N-ethylethanamine

1-bromo-4-((4-(difluoromethyl)phenoxy)methyl)benzene

Refernces

• 1、 Buerger, H.,Moritz, P.. "The synthesis and properties of (CH2F)SiH3 and related monofluoromethylsilanes". . p. 293 - 308. Retrieved 2007/10/02.