HEXAETHYLDISILOXANE

Base Information

• Chemical Name: HEXAETHYLDISILOXANE
• CAS No.: 994-49-0
• Molecular Formula: C12H30OSi2
• Molecular Weight: 246.541
• Hs Code.: 2934999090
• European Community (EC) Number: 213-619-8
• NSC Number: 139841
• UNII: S8VL2C7PE4
• DSSTox Substance ID: DTXSID1061362
• Nikkaji Number: J125.138D
• Wikidata: Q81989431
• Mol file: 994-49-0.mol

Synonyms:Disiloxane,hexaethyl- (6CI,8CI,9CI);1,1,1,3,3,3-Hexaethyldisiloxane;Bis(triethylsilyl)ether;Hexaethyldisiloxane;NSC 139841;

Chemical Property of HEXAETHYLDISILOXANE

Chemical Property:

• Vapor Pressure: 0.0805mmHg at 25°C
• Melting Point: -115 °C
• Refractive Index: 1.4330
• Boiling Point: 234.5 °C at 760 mmHg
• Flash Point: 77 °C
• PSA: 9.23000
• Density: 0.809 g/cm³
• LogP: 5.01340
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Not miscible or difficult to mix with water.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 8
• Exact Mass: 246.18351865
• Heavy Atom Count: 15
• Complexity: 129

Purity/Quality:

98%,99%, ^*data from raw suppliers

Hexaethyldisiloxane ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25-23

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC[Si](CC)(CC)O[Si](CC)(CC)CC
• Uses: Hexaethyldisiloxane is used as a pharmaceutical intermediate.

Technology Process of HEXAETHYLDISILOXANE

There total 261 articles about HEXAETHYLDISILOXANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

triethylsilane (617-86-7) + caprinaldehyde (112-31-2) → decyl ether (2456-28-2) + hexaethyl disiloxane (994-49-0)

Guidance literature:

With uranyl(VI) triflate; In dichloromethane-d2; at 20 ℃; for 0.1h;

DOI:10.1021/acscatal.9b01408

Reference yield: 72.5%

trimethylsilyl formate (18243-21-5) → N-formyldiethylamine (617-84-5) + Hexamethyldisiloxane (107-46-0) + 1,1,1-triethyl-3,3,3-trimethyl-disiloxane (2652-41-7) + hexaethyl disiloxane (994-49-0)

Guidance literature:

With N-Methylformamide; (diethylamino)triethylsilane; at 20 ℃; for 2h;

Reference yield: 72.5%

(diethylamino)triethylsilane (6022-10-2) → N-formyldiethylamine (617-84-5) + Hexamethyldisiloxane (107-46-0) + 1,1,1-triethyl-3,3,3-trimethyl-disiloxane (2652-41-7) + hexaethyl disiloxane (994-49-0)

Guidance literature:

With N-Methylformamide; trimethylsilyl formate; at 20 ℃; for 2h;

upstream raw materials:

triethylsilane

ethyl bromide

chloro-trimethyl-silane

diethyl ether

Downstream raw materials:

triethylsilane

triethylsilyl chloride

Bis(triethylsiloxy)diphenylaminosilan

triethylsilyl iodide

Refernces

• 1、 Anderson. "". . p. 1801. Retrieved 1949.
• 2、 Belli, Roman G.,Pantazis, Dimitrios A.,McDonald, Robert,Rosenberg, Lisa. "Reversible Silylium Transfer between P-H and Si-H Donors". supporting information. p. 2379 - 2384. Retrieved 2020/12/07.
• 3、 Fukuyama, Takahide,Hamada, Yuki,Ryu, Ilhyong. "A New Protocol for Catalytic Reduction of Alkyl Chlorides Using an Iridium/Bis(benzimidazol-2′-yl)pyridine Catalyst and Triethylsilane". supporting information. p. 3404 - 3408. Retrieved 2021/07/14.