2-Chloroethyl ethyl ether

Base Information

• Chemical Name: 2-Chloroethyl ethyl ether
• CAS No.: 628-34-2
• Molecular Formula: C4H9ClO
• Molecular Weight: 108.568
• Hs Code.: 29091900
• European Community (EC) Number: 211-037-9
• UNII: 2NLQ3AZ36L
• DSSTox Substance ID: DTXSID10211882
• Nikkaji Number: J1.699C
• Wikidata: Q72450086
• Mol file: 628-34-2.mol

Synonyms:2-Chloroethyl ethyl ether;628-34-2;1-CHLORO-2-ETHOXYETHANE;2-Ethoxyethyl chloride;2-Chloroethoxyethane;2-Chloroethylethylether;Ethane, 1-chloro-2-ethoxy-;1-chloro-2-ethoxy-ethane;Ether, 2-chloroethyl ethyl;beta-Chloroethyl ethyl ether;Ethyl beta-chloroethyl ether;CCRIS 9095;2-Chlorodiethyl ether;(2-chloroethoxy)ethane;beta-Chlorodiethyl ether;EINECS 211-037-9;BRN 1731361;Ethane, 1-chloro-2-ethoxy- (9CI);chloroethylethyl ether;chloroethyl ethyl ether;2-chloroethylethyl ether;2-chloroethyl-ethyl ether;2NLQ3AZ36L;1-chloranyl-2-ethoxy-ethane;Chloroethyl ethyl ether, 2-;SCHEMBL115596;.beta.-Chloroethyl ethyl ether;Ethyl .beta.-chloroethyl ether;DTXSID10211882;2-Chloroethyl ethyl ether, 99%;BCP15316;MFCD00000974;AKOS009157288;AS-75545;LS-67793;C1172;FT-0632655;EN300-51716;A834031;F0001-1693

Chemical Property of 2-Chloroethyl ethyl ether

Chemical Property:

• Appearance/Colour: clear colourless to slightly yellow liquid
• Melting Point: -60 °C
• Refractive Index: n20/D 1.411(lit.)
• Boiling Point: 107.5 °C at 760 mmHg
• Flash Point: 15.6 °C
• PSA: 9.23000
• Density: 0.989 g/cm³
• LogP: 1.26170
• Storage Temp.: Flammables area
• Water Solubility.: miscible
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 108.0341926
• Heavy Atom Count: 6
• Complexity: 23.5

Purity/Quality:

2-Chloroethyl ethyl ether ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xn
• Hazard Codes: F,Xn
• Statements: 11-20/22-41-36/37/38-2011/10/11
• Safety Statements: 36/37-37/39-26-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOCCCl
• Uses: It is used as a pharmaceutical intermediate. Photocatalytic oxidation of gaseous 2-chloroethyl ethyl sulfide over TiO2 illuminated with UV light and maintained at 25 or 80°C in air was found to suffer progressive oxidation to yield ethylene, chloroethylene , ethanol, acetaldehyde, chloroacetaldehyde, diethyl disulfide, 2-chloroethyl ethyl disulfide and bis(2-chloroethyl) disulfide as the main primary intermediates, and water (H2O), carbon dioxide (CO2), sulfur dioxide (SO2), surface sulfate ions (SO42-), and hydrogen chloride (HCl) as the final products.

Technology Process of 2-Chloroethyl ethyl ether

There total 21 articles about 2-Chloroethyl ethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethoxyethoxyethanol (111-90-0) + 3-chloro-3-(p-nitrophenyl)diazirine (39184-67-3) → 2-chloroethyl ethyl ether (628-34-2) + 2-(4-nitrophenyl)-1,3-dioxolane (2403-53-4) + 1-dichloromethyl-4-nitrobenzene (619-78-3)

Guidance literature:

at 80 ℃; for 6h;

Reference yield: 71.0%

tributylphosphine (998-40-3) + 2-chloro-4,6-bis(2-ethoxy-ethoxy)-1,3,5-triazine → 2-chloroethyl ethyl ether (628-34-2) + C19H36N3O3P

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 48h;

DOI:10.2478/s11532-012-0190-3

Reference yield: 70.0%

ethoxyethoxyethanol (111-90-0) + 3-chloro-3-phenyl-3H-diazirine (4460-46-2) → benzylidene dichloride (98-87-3) + 2-phenyl-1,3-dioxolane (936-51-6) + 2-chloroethyl ethyl ether (628-34-2) + benzaldehyde (100-52-7)

Guidance literature:

at 80 ℃; for 6h;

upstream raw materials:

2-ethoxy-ethanol

diethyl acetal

N,N-Dichlorobenzenesulfonamide

ethanol

Downstream raw materials:

monoethylene glycol diethyl ether

1-ethyl-4-phenylethylene glycol

2-iodoethyl ethyl ether

2-mercaptoethyl ether

Refernces

• 1、 Kolesinska, Beata,Mrozek, Agnieszka,Fraczyk, Justyna,Kaminski, Zbigniew J.. "P-Triazinylphosphonium chlorides as a new group of coupling reagents". . p. 569 - 583. Retrieved 2013/08/24.
• 2、 Tanaka, Mutsuo,Kamada, Kenji,Ando, Hisanori,Kitagaki, Takashi,Shibutani, Yasuhiko,Kimura, Keiichi. "Synthesis and Photochromism of Crowned Spirobenzothiapyran: Facilitated Photoisomerization by Cooperative Complexation of Crown Ether and Thiophenolate Moieties with Metal Ions". . p. 4342 - 4347. Retrieved 2007/10/03.