Benzamide, N-acetyl-4-methoxy-

Base Information

• Chemical Name: Benzamide, N-acetyl-4-methoxy-
• CAS No.: 73894-89-0
• Molecular Formula: C10H11NO3
• Molecular Weight: 193.202
• DSSTox Substance ID: DTXSID60434483
• Nikkaji Number: J1.140.846J
• Wikidata: Q82248920
• Mol file: 73894-89-0.mol

Synonyms:Benzamide, N-acetyl-4-methoxy-;73894-89-0;4-Methoxy-N-acetylbenzamide;SCHEMBL7915810;DTXSID60434483

Chemical Property of Benzamide, N-acetyl-4-methoxy-

Chemical Property:

• PSA: 58.89000
• LogP: 1.81180
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 193.07389321
• Heavy Atom Count: 14
• Complexity: 219

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)NC(=O)C1=CC=C(C=C1)OC

Technology Process of Benzamide, N-acetyl-4-methoxy-

There total 17 articles about Benzamide, N-acetyl-4-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-methoxyphenylacetamide (3424-93-9) + acetic anhydride (108-24-7) → acetyl-p-methoxybenzoylimide (73894-89-0)

Guidance literature:

With sulfuric acid; at 100 ℃; for 0.05h; Microwave irradiation;

DOI:10.1016/j.tet.2012.01.003

Reference yield: 85.0%

acetic anhydride (108-24-7) + 4-methoxybenzonitrile (874-90-8) → acetyl-p-methoxybenzoylimide (73894-89-0)

Guidance literature:

With toluene-4-sulfonic acid; for 0.116667h; Sonication; neat (no solvent);

DOI:10.2298/JSC110511168N

Reference yield: 83.0%

N-(p-methoxybenzyl)acetamide (35103-34-5) → acetyl-p-methoxybenzoylimide (73894-89-0)

Guidance literature:

With potassium fluoride; ammonium persulfate; copper(ll) sulfate pentahydrate; silver nitrate; In water; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.3184/174751912X13567968693695

upstream raw materials:

acetamide

4-methoxy-benzoyl chloride

2-(4-methoxyphenyl)-4-methyl-5-oxo-4,5-dihydrooxazole

4-methoxyphenylacetamide

Downstream raw materials:

5-(4-methoxyphenyl)-3-methyl-1-phenyl-1H-1,2,4-triazole

Refernces

• 1、 -. "Method for catalytically oxidizing amine to be synthesized into amide through dipyridyl-type manganese catalyst". Paragraph 0017-0027; 0061-0063. . Retrieved 2019/06/30.
• 2、 Hu, Yixin,Zhou, Lihong,Lu, Wenjun. "Transition-Metal- and Halogen-Free Oxidation of Benzylic sp 3 C-H Bonds to Carbonyl Groups Using Potassium Persulfate". supporting information. p. 4007 - 4016. Retrieved 2017/08/29.