Pyrazine-2,3-dicarboxamide

Base Information

• Chemical Name: Pyrazine-2,3-dicarboxamide
• CAS No.: 6164-78-9
• Molecular Formula: C6H6N4O2
• Molecular Weight: 166.139
• Hs Code.: 2934999090
• European Community (EC) Number: 228-197-0
• NSC Number: 93820
• UNII: 3D1IC3QEXF
• DSSTox Substance ID: DTXSID90210656
• Nikkaji Number: J230E
• Wikidata: Q27257051
• Mol file: 6164-78-9.mol

Synonyms:Pyrazine-2,3-dicarboxamide;2,3-Pyrazinedicarboxamide;6164-78-9;UNII-3D1IC3QEXF;3D1IC3QEXF;2,3-Pyrazinedicarboxylic acid, diamide;EINECS 228-197-0;NSC 93820;NSC-93820;AI3-61138;2, diamide;NSC93820;SCHEMBL2492969;TZMYZOQDDVSLJU-UHFFFAOYSA-;2,3-DICARBOXAMIDOPYRAZINE;DTXSID90210656;2,3-Pyrazinedicarboxamide, 95%;AKOS017344468;2,3-PYRAZINEDICARBOXYLIC ACID DIAMIDE;FT-0636012;A833349;AC-907/25014119;2,3-PYRAZINEDICARBOXYLIC ACID DIAMIDE [MI];Q27257051

Chemical Property of Pyrazine-2,3-dicarboxamide

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 2.55E-13mmHg at 25°C
• Melting Point: 248 °C (dec.)(lit.)
• Refractive Index: 1.62
• Boiling Point: 505.1 °C at 760 mmHg
• PKA: 13.23±0.50(Predicted)
• Flash Point: 259.3 °C
• PSA: 111.96000
• Density: 1.466 g/cm³
• LogP: 0.07500
• XLogP3: -2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 166.04907545
• Heavy Atom Count: 12
• Complexity: 184

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3-Pyrazinedicarboxamide 95% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C(=N1)C(=O)N)C(=O)N

Technology Process of Pyrazine-2,3-dicarboxamide

There total 6 articles about Pyrazine-2,3-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.3%

pyrazine-2,3-dicarboxylic acid dimethyl ester (6164-77-8) → pyrazine-2,3-dicarboxamide (6164-78-9)

Guidance literature:

With ammonia; In methanol; Heating;

Reference yield: 15.0%

dimethyl pyrazine-2,3-dicarboimidate (68572-99-6) → pyrazine-2,3-dicarboxamide (6164-78-9) + 3-(aminocarbonyl)pyrazinecarboxylic acid, methyl ester (75018-17-6)

Guidance literature:

With hydrogenchloride; for 8h; Ambient temperature;

Reference yield:

3-cyanopyrazine-2-carboxylic acid (70546-26-8) → pyrazine-2,3-dicarboxamide (6164-78-9)

Guidance literature:

With K₃Na[Mo(CN)₄O₂]·6H₂O; In ethanol; water; at 39.84 ℃; pH=8.5;

DOI:10.1016/j.poly.2012.07.006

upstream raw materials:

pyrazine-2,3-dicarboxylic acid dimethyl ester

dimethyl pyrazine-2,3-dicarboimidate

2,3-dicarboxypyrazine

pyrazine-2,3-dicarbonitrile

Downstream raw materials:

3-aminopyrazinoic acid

3-amidecarbonylpyrazine-2-carboxylic acid

Lumazine

5H pyrrolo[3,4-b]pyrazine-5,7(6H)-dione

Refernces

• 1、 Tsuda, Tadataka,Fujishima, Katsuhiro,Ueda, Hiroo. "Synthesis of Pyrazinedicarboximides from Diaminomaleonitrile". . p. 2129 - 2130. Retrieved 2007/10/02.