Pyrazinecarboxylic acid, 3-cyano- (9CI)

Base Information

• Chemical Name: Pyrazinecarboxylic acid, 3-cyano- (9CI)
• CAS No.: 70546-26-8
• Molecular Formula: C6H3N3O2
• Molecular Weight: 149.109
• Mol file: 70546-26-8.mol

Synonyms:Pyrazinecarboxylic acid, 3-cyano- (9CI)

Chemical Property of Pyrazinecarboxylic acid, 3-cyano- (9CI)

Chemical Property:

• PSA: 86.87000
• LogP: 0.04648

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazinecarboxylic acid, 3-cyano- (9CI)

There total 4 articles about Pyrazinecarboxylic acid, 3-cyano- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl 3-cyanopyrazine-2-carboxylate (74402-57-6) → 3-cyanopyrazine-2-carboxylic acid (70546-26-8)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 3h;

DOI:10.1007/s11224-016-0870-2

Reference yield:

3-cyanopyrazine-2-carboxamide (66505-29-1) → 3-cyanopyrazine-2-carboxylic acid (70546-26-8)

Guidance literature:

With K₃Na[Mo(CN)₄O₂]·6H₂O; In ethanol; water; at 39.84 ℃; pH=8.5;

DOI:10.1016/j.poly.2012.07.006

Reference yield:

3-amidecarbonylpyrazine-2-carboxylic acid (67367-37-7) → 3-cyanopyrazine-2-carboxylic acid (70546-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: sodium hydroxide; water / methanol / 3 h / 20 °C

2.2: Cooling

With water; triethylamine; sodium hydroxide; In methanol; dichloromethane;

DOI:10.1016/j.tet.2016.04.069

upstream raw materials:

pyrazine-2,3-dicarbonitrile

3-cyanopyrazine-2-carboxamide

3-amidecarbonylpyrazine-2-carboxylic acid

methyl 3-cyanopyrazine-2-carboxylate

Downstream raw materials:

pyrazine-2,3-dicarboxamide

2,3-dicarboxypyrazine

Refernces

• 1、 Ovdiichuk, Olga,Hordiyenko, Olga,Fotou, Evgenia,Gaucher, Caroline,Arrault, Axelle,Averlant-Petit, Marie-Christine. "Conformational studies of new pseudotripeptide with pyrazine amidoxime motif and simplified analogs using IR, NMR spectroscopy, and molecular dynamic simulations". . p. 813 - 822. Retrieved 2017/05/10.