Picolinamide, 6-amino- (6CI,7CI,8CI)

Base Information

• Chemical Name: Picolinamide, 6-amino- (6CI,7CI,8CI)
• CAS No.: 13538-41-5
• Molecular Formula: C6H7N3O
• Molecular Weight: 137.141
• Hs Code.: 2933399090
• Mol file: 13538-41-5.mol

Synonyms:Picolinamide,6-amino- (6CI,7CI,8CI);NSC 522598;

Chemical Property of Picolinamide, 6-amino- (6CI,7CI,8CI)

Chemical Property:

• Vapor Pressure: 2.27E-05mmHg at 25°C
• Melting Point: 145 °C(Solv: water (7732-18-5))
• Refractive Index: 1.643
• Boiling Point: 360.1 °C at 760 mmHg
• PKA: 15.33±0.50(Predicted)
• Flash Point: 171.6 °C
• PSA: 82.00000
• Density: 1.323 g/cm³
• LogP: 1.04420

Purity/Quality:

99% ^*data from raw suppliers

6-Amino-pyridine-2-carboxylicacidamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Picolinamide, 6-amino- (6CI,7CI,8CI)

There total 5 articles about Picolinamide, 6-amino- (6CI,7CI,8CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-aminopyridine-2-carbonitrile → 6-aminopyridine-2-carboxamide (13538-41-5)

Guidance literature:

With silica-gel-supported sulfuric acid; In toluene; for 3h; Inert atmosphere; Reflux;

DOI:10.14233/ajchem.2016.19907

Reference yield: 13.0%

6-bromo-pyridine-2-carboxylic acid (21190-87-4) → 6-aminopyridine-2-carboxamide (13538-41-5)

Guidance literature:

With ammonia; In water; at 200 ℃; for 17h;

DOI:10.3987/COM-11-12290

Reference yield:

methyl 6-aminopyridine-2-carboxylate (36052-26-3) → 6-aminopyridine-2-carboxamide (13538-41-5)

Guidance literature:

With ammonium hydroxide;

upstream raw materials:

methyl 6-aminopyridine-2-carboxylate

2-acetylamino-6-methylpyridine

6-acetamido-picolinic acid

6-bromo-pyridine-2-carboxylic acid

Downstream raw materials:

6-aminopicolinic acid

methyl 6-aminopyridine-2-carboxylate

Refernces

• 1、 Okamoto, Iwao,Terashima, Masayuki,Yoshioka, Rempei,Muramatsu, Tomonori,Kojima, Satomi,Inoue, Haruka,Takahashi, Mio,Morita, Nobuyoshi,Tamura, Osamu. "Convenient synthesis of aminopyridinecarboxylic acids". experimental part. p. 2343 - 2352. Retrieved 2011/11/06.