6-Acetamidopicolinic acid

Base Information

• Chemical Name: 6-Acetamidopicolinic acid
• CAS No.: 26893-72-1
• Molecular Formula: C8H8N2O3
• Molecular Weight: 180.163
• Hs Code.: 29333990
• DSSTox Substance ID: DTXSID30356461
• Nikkaji Number: J101.882E
• Wikidata: Q82135795
• ChEMBL ID: CHEMBL1390646
• Mol file: 26893-72-1.mol

Synonyms:6-Acetamidopicolinic acid;26893-72-1;6-acetamidopyridine-2-carboxylic acid;6-(acetylamino)-2-pyridinecarboxylic acid;6-(acetylamino)pyridine-2-carboxylic acid;MFCD00233707;6-acetylaminopyridine-2-carboxylic acid;6-Acetamidopicolinic acid, 6-(Acetylamino)pyridine-2-carboxylic acid;2-Pyridinecarboxylic acid, 6-(acetylamino)-;EC-000.1966;MLS000704785;Picolinic acid, 6-acetamido-;SCHEMBL2251120;CHEMBL1390646;AML0068;DTXSID30356461;HMS2620F21;AKOS001289630;SB52862;2-acetylaminopyridine-6-carboxylic acid;6-Acetylamino-2-pyridinecarboxylic acid;6-Acetylamino-pyridine-2-carboxylic acid;AS-48013;SMR000230414;FT-0687912;EN300-26425;F17538;A877106;AC-907/34126046;J-518190;6-(acetylamino)-2-pyridinecarboxylic acid, AldrichCPR;Z223026202;6-Acetamidopicolinicacid,6-(Acetylamino)pyridine-2-carboxylicacid

Chemical Property of 6-Acetamidopicolinic acid

Chemical Property:

• Vapor Pressure: 2.25E-10mmHg at 25°C
• Melting Point: 227-229 °C(Solv: ethanol (64-17-5))
• Refractive Index: 1.628
• Boiling Point: 489 °C at 760 mmHg
• PKA: 3.43±0.10(Predicted)
• Flash Point: 249.5 °C
• PSA: 79.29000
• Density: 1.404 g/cm³
• LogP: 0.81120
• Storage Temp.: 2-8°C
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 180.05349212
• Heavy Atom Count: 13
• Complexity: 217

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

6-AcetamidopicolinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=CC(=N1)C(=O)O
• Uses: 6-Acetamidopicolinic Acid is a chemical reagent used in the synthesis of calixarene based picolinamide ligands for use in radioactive waste treatment

Technology Process of 6-Acetamidopicolinic acid

There total 5 articles about 6-Acetamidopicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-acetylamino-6-methylpyridine (5327-33-3) → 6-acetamido-picolinic acid (26893-72-1)

Guidance literature:

With potassium permanganate; water; at 80 ℃; for 5h;

DOI:10.1039/c6ob00592f

Reference yield: 32.0%

6-(acetylamino)-2-methylpyridinium acetate → 6-acetamido-picolinic acid (26893-72-1)

Guidance literature:

With sodium hydroxide; potassium permanganate; for 0.5h; Heating;

DOI:10.1002/chem.200400652

Reference yield:

2-Amino-6-methylpyridine (1824-81-3) → 6-acetamido-picolinic acid (26893-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / toluene / 95 °C

2: 32 percent / aq. NaOH; KMnO₄ / 0.5 h / Heating

With sodium hydroxide; potassium permanganate; In toluene;

DOI:10.1002/chem.200400652

upstream raw materials:

2-acetylamino-6-methylpyridine

2-Amino-6-methylpyridine

acetic anhydride

Downstream raw materials:

N-(6-{3-[4-({[3-(acetylamino)phenyl]amino}sulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}pyridin-2-yl)acetamide

N-(6-{3-[4-(benzylthio)phenyl]-1,2,4-oxadiazol-5-yl}pyridin-2-yl)acetamide

(6-Amino-pyridin-2-yl)-methanol

methyl 6-amino-3-bromo-pyridine-2-carboxylate

Refernces

• 1、 -. "NOVEL COMPOUND, ORGANIC CATION TRANSPORTER 3 DETECTION AGENT, AND ORGANIC CATION TRANSPORTER 3 ACTIVITY INHIBITOR". Paragraph 0543-0544; 0546. . Retrieved 2016/08/17.
• 2、 -. "GAMMA SECRETASE MODULATERS". Page/Page column 129. . Retrieved 2011/08/21.