Methyl 6-amino-3-bromopicolinate

Base Information

• Chemical Name: Methyl 6-amino-3-bromopicolinate
• CAS No.: 178876-83-0
• Molecular Formula: C7H7 Br N2 O2
• Molecular Weight: 231.049
• Hs Code.: 2933399090
• European Community (EC) Number: 689-876-9
• DSSTox Substance ID: DTXSID80443118
• Wikidata: Q72486753
• Mol file: 178876-83-0.mol

Synonyms:METHYL 6-AMINO-3-BROMOPICOLINATE;178876-83-0;Methyl 6-amino-3-bromopyridine-2-carboxylate;6-amino-3-bromo-pyridine-2-carboxylic acid methyl ester;2-Pyridinecarboxylic acid, 6-amino-3-bromo-, methyl ester;MFCD09800897;methyl6-amino-3-bromopicolinate;SCHEMBL1268827;DTXSID80443118;YJUKTIBOUBUOJH-UHFFFAOYSA-N;AKOS015854648;SB21246;AC-29616;AM807580;DS-13718;SY040740;2-amino-5-bromo-6-methoxycarbonylpyridine;A3965;CS-0041829;FT-0652729;EN300-2008371;methyl 6-amino-3-bromopicolinate;Methyl 6-Amino-3-bromopyridine-2-carboxylate

Chemical Property of Methyl 6-amino-3-bromopicolinate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.608
• Boiling Point: 333.4°Cat760mmHg
• PKA: 1.12±0.10(Predicted)
• Flash Point: 155.4°C
• PSA: 65.21000
• Density: 1.662g/cm³
• LogP: 1.79410
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 229.96909
• Heavy Atom Count: 12
• Complexity: 177

Purity/Quality:

99% ^*data from raw suppliers

Methyl6-Amino-3-bromopyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1=C(C=CC(=N1)N)Br

Technology Process of Methyl 6-amino-3-bromopicolinate

There total 12 articles about Methyl 6-amino-3-bromopicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

methyl 6-aminopyridine-2-carboxylate (36052-26-3) → methyl 6-amino-3-bromo-pyridine-2-carboxylate (178876-83-0)

Guidance literature:

methyl 6-aminopyridine-2-carboxylate; With bromine; sodium carbonate; acetic acid; at 10 - 35 ℃; for 7h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield: 25.0%

methyl 6-aminopyridine-2-carboxylate (36052-26-3) → methyl 6-amino-3-bromo-pyridine-2-carboxylate (178876-83-0) + 6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester (178876-82-9)

Guidance literature:

With bromine; In chloroform;

DOI:10.1021/jo960433d

Reference yield: 19.0%

methyl 6-aminopyridine-2-carboxylate (36052-26-3) → methyl 6-amino-3,5-dibromopicolinate (443956-21-6) + methyl 6-amino-3-bromo-pyridine-2-carboxylate (178876-83-0) + 6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester (178876-82-9)

Guidance literature:

With bromine; In chloroform; at 20 ℃;

upstream raw materials:

methyl 6-aminopyridine-2-carboxylate

2-Amino-6-methylpyridine

2-acetylamino-6-methylpyridine

6-acetamido-picolinic acid

Downstream raw materials:

methyl 3-bromo-6-(dibenzylamino)pyridine-2-carboxylate

4-({[6-methoxy-2-(4-fluoro-3-methyl-benzylcarbamoyl)-imidazo[1,2-a]pyridine-5-carbonyl]-amino}-methyl)-benzoic acid methyl ester

4-({[6-methoxy-2-(4-fluoro-3-methyl-benzylcarbamoyl)-imidazo[1,2-a]pyridine-5-carbonyl]-amino}-methyl)-benzoic acid

4-({[6-bromo-2-(4-fluoro-3-methyl-benzylcarbamoyl)-imidazo[1,2-a]pyridine-5-carbonyl]-amino}-methyl)-benzoic acid methyl ester

Refernces

• 1、 -. "TRISUBSTITUTED HETEROCYCLIC DERIVATIVES AS ROR GAMMA MODULATORS". . . Retrieved 2014/09/03.
• 2、 -. "APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES". Paragraph 1777. . Retrieved 2013/04/24.