Methanesulfonamide, N-phenyl-N-(3-phenyl-2-propynyl)-

Base Information

• Chemical Name: Methanesulfonamide, N-phenyl-N-(3-phenyl-2-propynyl)-
• CAS No.: 809274-73-5
• Molecular Formula: C16H15NO2S
• Molecular Weight: 285.367
• Mol file: 809274-73-5.mol

Synonyms:

Chemical Property of Methanesulfonamide, N-phenyl-N-(3-phenyl-2-propynyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonamide, N-phenyl-N-(3-phenyl-2-propynyl)-

There total 1 articles about Methanesulfonamide, N-phenyl-N-(3-phenyl-2-propynyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

3-Phenyl-2-propyn-1-ol (1504-58-1) + N-phenylmethanesulfonamide (1197-22-4) → N-phenyl-N-(3-phenyl-2-propyn-1-yl)methanesulfonamide (809274-73-5)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

DOI:10.1021/ol0476218 DOI:10.1021/jo048788h

Reference yield: 81.0%

N-phenyl-N-(3-phenyl-2-propyn-1-yl)methanesulfonamide (809274-73-5) → 3-iodo-1-methanesulfonyl-4-phenyl-1,2-dihydroquinoline (809274-74-6)

Guidance literature:

With tetrafluoroboric acid; [bis(pyridine)iodine]⁺ tetrafluoroborate; In dichloromethane; at -80 ℃;

DOI:10.1039/b500303b

Reference yield:

N-phenyl-N-(3-phenyl-2-propyn-1-yl)methanesulfonamide (809274-73-5) → 3-iodo-4-phenylquinoline (809274-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / ICl / CH₂Cl₂ / 1 h / -78 °C

2: 92 percent / NaOH; O₂ / ethanol / 12 h / 50 °C / 760 Torr

With sodium hydroxide; oxygen; Iodine monochloride; In ethanol; dichloromethane;

DOI:10.1021/ol0476218 DOI:10.1021/jo048788h

upstream raw materials:

3-Phenyl-2-propyn-1-ol

N-phenylmethanesulfonamide

Downstream raw materials:

3-iodo-1-methanesulfonyl-4-phenyl-1,2-dihydroquinoline

indeno[1,2,3-de]quinoline

3-iodo-4-phenylquinoline

Refernces

• 1、 Huang, Qinhua,Campo, Marino A.,Yao, Tuanli,Tian, Qingping,Larock, Richard C.. "Synthesis of fused polycycles by 1,4-palladium migration chemistry". . p. 8251 - 8257. Retrieved 2007/10/03.