2,2'-Oxybis(ethylamine) dihydrochloride

Base Information

• Chemical Name: 2,2'-Oxybis(ethylamine) dihydrochloride
• CAS No.: 60792-79-2
• Molecular Formula: C4H14Cl2N2O
• Molecular Weight: 177.074
• Hs Code.: 2922199090
• European Community (EC) Number: 262-435-4
• UNII: MJ9SN78NYT
• DSSTox Substance ID: DTXSID70209624
• Wikidata: Q27284060
• Mol file: 60792-79-2.mol

Synonyms:2,2'-Oxybis(ethylamine) dihydrochloride;60792-79-2;2,2'-Oxydiethylamine dihydrochloride;2,2'-oxybis(ethylamine)dihydrochloride;2-(2-aminoethoxy)ethanamine;dihydrochloride;Ethanamine, 2,2'-oxybis-, dihydrochloride;EINECS 262-435-4;UNII-MJ9SN78NYT;2,2'-Oxydiethanamine dihydrochloride;MJ9SN78NYT;2,2'-Oxybis(ethylamine) hydrochloride;2-(2-aminoethoxy)ethanamine dihydrochloride;2,2'-oxybis(ethylamine) 2hcl;Bis(2-aminoethyl) Ether Dihydrochloride;2-(2-aminoethoxy)ethan-1-amine dihydrochloride;2-Aminoethyl ether dihydrochloride;122022-47-3;2-(2-Aminoethoxy)ethanamine,dihydrochloride;Cambridge id 5129625;2,2'-oxydiethanamine 2hcl;C4H12N2O.2ClH;SCHEMBL285085;AMY7556;DTXSID70209624;KTCUXFVANABSPX-UHFFFAOYSA-N;C4-H12-N2-O.2Cl-H;MFCD00012891;2,2/'-Oxydiethylamine dihydrochloride;AKOS016002971;CS-W006284;2,2'-oxy-bis(ethylamine)dihydrochloride;1,5-diamino-3-oxapentane dihydrochloride;2,2'-oxy-bis(ethylamine) dihydrochloride;AS-40334;2,2'-Diaminodiethyl Ether Dihydrochloride;2,2'-Oxydiethylamine dihydrochloride, 97%;2-(2-aminoethoxy)-ethanamine dihydrochloride;2-(2-aminoethoxyl)ethanamine dihydrochloride;FT-0609312;O0263;EN300-7398805;A868889;ETHYLAMINE, 2,2'-OXYBIS-, DIHYDROCHLORIDE;2,2'-Oxybis(ethylamine) Dihydrochloride, >/=97%;Q27284060;ETHANAMINE, 2,2'-OXYBIS-, HYDROCHLORIDE (1:2)

Chemical Property of 2,2'-Oxybis(ethylamine) dihydrochloride

Chemical Property:

• Appearance/Colour: white to light beige crystalline powder
• Melting Point: 230-234 °C(lit.)
• Boiling Point: 185.9 °C at 760 mmHg
• Flash Point: 74.8 °C
• PSA: 61.27000
• LogP: 1.92500
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: within almost transparency
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 176.0483185
• Heavy Atom Count: 9
• Complexity: 28.9

Purity/Quality:

98%, ^*data from raw suppliers

2,2'-Oxybis(ethylamine) Dihydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(COCCN)N.Cl.Cl
• Uses: 2,2''-Oxybis(ethylamine) Dihydrochloride can be used as reactant/reagent in polyboramines for hydrogen release: polymers containing Lewis pairs in their backbone. It can also be used in synthetic preparation and antitrypanosomal activity of adenosines via amination of chloropurinyl deoxyribofuranose with aminoethoxy ethylamine, followed by polymer-supported acylation of carboxylic acids.

Technology Process of 2,2'-Oxybis(ethylamine) dihydrochloride

There total 2 articles about 2,2'-Oxybis(ethylamine) dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,2'-diaminodiethyl ether (2752-17-2) → 2-(2-aminoethoxy)ethanamine dihydrochloride (60792-79-2)

Guidance literature:

With hydrogenchloride; In diethyl ether; water; Cooling with ice;

DOI:10.1016/j.ejmech.2009.02.010

Reference yield: 89.0%

2,2'-diphthalimido-diethyl ether (43113-25-3) → 2-(2-aminoethoxy)ethanamine dihydrochloride (60792-79-2)

Guidance literature:

With hydrogenchloride; hydrazine hydrate; 1.) methanol, 1 h, reflux; 2.) water, 1 h, reflux;

DOI:10.1021/j100135a022

Reference yield: 97.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-(2-aminoethoxy)ethanamine dihydrochloride (60792-79-2) → tert-butyl 2-(2-aminoethoxy)ethylcarbamate (127828-22-2) + di-tert-butyl 3-oxapentane-1,5-diyldicarbamate

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 24h;

DOI:10.1002/1099-0690(200209)2002:17<3004::AID-EJOC3004>3.0.CO;2-O

upstream raw materials:

2,2'-diphthalimido-diethyl ether

2,2'-diaminodiethyl ether

Downstream raw materials:

2,2'-diaminodiethyl ether

1,7-bis(phenylcarbonyl)-4-oxa-1,7-diazaheptane

N,N'-Bis(p-tolylsulfonyl)-1,5-diamino-3-oxapentane

tert-butyl 2-(2-aminoethoxy)ethylcarbamate

Refernces

• 1、 Griffin, Jonathan L. W.,Coveney, Peter V.,Whiting, Andrew,Davey, Roger. "Design and synthesis of macrocyclic ligands for specific interaction with crystalline ettringite and demonstration of a viable mechanism for the setting of cement". . p. 1973 - 1981. Retrieved 2007/10/03.