butyl 2-chlorobenzoate

Base Information

• Chemical Name: butyl 2-chlorobenzoate
• CAS No.: 52468-48-1
• Molecular Formula: C11H13 Cl O2
• Molecular Weight: 212.676
• Mol file: 52468-48-1.mol

Synonyms:Benzoic acid,o-chloro-, butyl ester (7CI); Butyl 2-chlorobenzoate; Butyl o-chlorobenzoate;NSC 8228; n-Butyl 2-chlorobenzoate

Chemical Property of butyl 2-chlorobenzoate

Chemical Property:

• Vapor Pressure: 0.00414mmHg at 25°C
• Boiling Point: 278.9°Cat760mmHg
• Flash Point: 129.8°C
• Density: 1.126g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of butyl 2-chlorobenzoate

There total 10 articles about butyl 2-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-Chlorobenzyl alcohol (17849-38-6) + butan-1-ol (71-36-3) → butyl 2-chlorobenzoate (52468-48-1)

Guidance literature:

With dihydrogen peroxide; bromine; In dichloromethane; water; for 4h; Reflux;

Reference yield: 78.0%

carbon monoxide (201230-82-2) + 2-iodochlorobenzene (615-41-8) + butan-1-ol (71-36-3) → butyl 2-chlorobenzoate (52468-48-1)

Guidance literature:

With potassium phosphate; Pd/Fe₃O₄; In N,N-dimethyl-formamide; at 80 ℃; for 10h;

DOI:10.1016/j.molcata.2013.01.002

Reference yield: 75.0%

2-Chlorophenylacetonitrile (2856-63-5) + butan-1-ol (71-36-3) → butyl 2-chlorobenzoate (52468-48-1)

Guidance literature:

With pyridine; ferric(III) bromide; oxygen; In chlorobenzene; at 130 ℃; for 9h; Sealed tube;

DOI:10.1021/acs.joc.6b01594

upstream raw materials:

1-Chloro-2-dibutoxymethyl-benzene

2-Chlorobenzonitrile

butan-1-ol

carbon monoxide

Downstream raw materials:

ortho-diphenylphosphinobenzoic acid

Refernces

• 1、 Tien, Chieh-Hung,Trofimova, Alina,Holownia, Aleksandra,Kwak, Branden S.,Larson, Reed T.,Yudin, Andrei K.. "Carboxyboronate as a Versatile In Situ CO Surrogate in Palladium-Catalyzed Carbonylative Transformations". supporting information. p. 4342 - 4349. Retrieved 2020/12/25.
• 2、 Kong, Weiguang,Li, Bingnan,Xu, Xuezhao,Song, Qiuling. "Fe-Catalyzed Aerobic Oxidative C-CN Bond Cleavage of Arylacetonitriles Leading to Various Esters". . p. 8436 - 8443. Retrieved 2016/09/28.