Aminopterin

Base Information Edit

Chemical Name:Aminopterin
CAS No.:54-62-6
Deprecated CAS:120382-78-7,64801-55-4
Molecular Formula:C19H20N8O5
Molecular Weight:440.418
Hs Code.:29339900
European Community (EC) Number:200-209-9
UN Number:2811,2588
UNII:JYB41CTM2Q
DSSTox Substance ID:DTXSID3022588
Nikkaji Number:J2.313B
Wikipedia:Aminopterin
Wikidata:Q415734
NCI Thesaurus Code:C235
RXCUI:1440263
Pharos Ligand ID:JWX6H3GV2TVV
Metabolomics Workbench ID:53878
ChEMBL ID:CHEMBL376180
Mol file:54-62-6.mol

Synonyms:Aminopterin;Aminopterin Sodium;Aminopterin, Disodium Salt;Disodium Salt Aminopterin;Sodium, Aminopterin

Suppliers and Price of Aminopterin

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Aminopterin
50mg
$ 460.00

TRC
Aminopterin
25mg
$ 65.00

TRC
Aminopterin
500mg
$ 345.00

TCI Chemical
Aminopterin Hydrate >97.0%(HPLC)(T)
100mg
$ 402.00

TCI Chemical
Aminopterin Hydrate >97.0%(HPLC)(T)
25mg
$ 135.00

Sigma-Aldrich
Aminopterin powder
50mg
$ 299.00

Sigma-Aldrich
Aminopterin powder, BioReagent, suitable for cell culture
25mg
$ 141.00

Sigma-Aldrich
Aminopterin Hybri-Max?, 50?×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma
10 vials
$ 70.80

Sigma-Aldrich
Aminopterin powder, BioReagent, suitable for cell culture
10mg
$ 73.00

Sigma-Aldrich
Aminopterin Hybri-Max , 50 ×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma
10vl
$ 68.30

Total 66 raw suppliers

Chemical Property of Aminopterin Edit

Chemical Property:

Appearance/Colour:Yellow solid.
Melting Point:228-235 °C (dec.)
Refractive Index:1.761
Boiling Point:551.67°C (rough estimate)
PKA:pKa 5.5 (Uncertain)
Flash Point:87℃
PSA：219.33000
Density:1.589 g/cm³
LogP:1.87040
Storage Temp.:2-8°C
Solubility.:2 M NaOH: 50 mg/mL
Water Solubility.:2 M NaOH: 50 mg/mL
XLogP3:-2
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:9
Exact Mass:440.15566577
Heavy Atom Count:32
Complexity:674
Transport DOT Label:Poison

Purity/Quality:: Aminopterin ^*data from reagent suppliers

Safty Information:

Pictogram(s): T+
Hazard Codes:T+
Statements: 61-28-63-26/27/28
Safety Statements: 53-28-36/37-45-36/37/39-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Chemical Classes:Pesticides -> Rodenticides
Canonical SMILES:C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=NC(=N3)N)N
Isomeric SMILES:C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=NC(=N3)N)N
Recent ClinicalTrials:Aminopterin Pharmacokinetic Study In Moderate to Severe Psoriasis
Uses Aminopterin has been used in the production of anti- neurogranin antibodies. A folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity. antineoplastic, antirheumatic, folic acid antagonist
Therapeutic Function Antineoplastic

Technology Process of Aminopterin

There total 21 articles about Aminopterin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%