52853-40-4 Usage
Description
6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR, also known as 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide, is a light brown solid with significant applications in the fields of organic and pharmaceutical synthesis. It serves as an intermediate in the development of various compounds, particularly those with potential therapeutic uses.
Uses
Used in Organic Synthesis:
6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR is used as an organic synthesis intermediate for the creation of novel chemical compounds. Its unique structure allows for the development of a wide range of products with diverse applications.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR is used as a pharmaceutical intermediate. It plays a crucial role in the preparation of new drugs, contributing to the advancement of medical treatments.
Used in Antirheumatic Applications:
6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR is used as a key component in the preparation of methotrexate derivatives, which are known for their antirheumatic properties. These derivatives help in managing the symptoms and progression of rheumatic diseases.
Used in Enzyme Inhibition:
6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR is also utilized in the preparation of pteridine reductase inhibitors. These inhibitors are essential in studying the function and role of pteridine reductase enzymes, which are involved in various biological processes and can be targeted for therapeutic intervention in certain diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 52853-40-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,8,5 and 3 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 52853-40:
(7*5)+(6*2)+(5*8)+(4*5)+(3*3)+(2*4)+(1*0)=124
124 % 10 = 4
So 52853-40-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H7BrN6.BrH/c8-1-3-2-11-6-4(12-3)5(9)13-7(10)14-6;/h2H,1H2,(H4,9,10,11,13,14);1H
52853-40-4Relevant articles and documents
USE OF THE STAUDINGER LIGATION IN IN VIVO ASSEMBLY OF A BIOLOGICALLY ACTIVE COMPOUND
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Page/Page column 23, (2008/06/13)
The invention provides methods and tools for the in vivo self-assembly of drugs. This makes it possible to reduce problems associated with the lack of selectivity, reduced solubility and other disadvantages of intact drugs.
Compositions and methods employing aminopterin
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Page/Page column 17, (2008/06/13)
The present invention relates to pharmaceutical compositions containing the antifolate aminopterin, processes for making the compositions, and methods of using them to treat disorders in adult and pediatric patients. Pharmaceutical compositions substantially free of impurities are provided comprising a therapeutically effective amount of aminopterin, or a pharmaceutically acceptable salt thereof. Relative to the teachings of the prior art, the disclosed methods and compositions provide unexpected improvements that include a greater interpatient oral bioavailability in pediatric patients, a smaller interpatient coefficient of variation of oral bioavailability, a smaller mean intrapatient coefficient of variation of oral bioavailability, a greater therapeutic index, a smaller coefficient of variation of toxicity, efficacy in combination therapy, and efficacy of certain polyglutamated metabolites.
Pteridine derivatives and method of treating leukemia employing same
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, (2008/06/13)
2,4-Diaminopteridine derivatives and the pharmaceutically acceptable salts thereof having potent anticancer activity are disclosed. The derivatives possess the structural formula: STR1 wherein Y is NH2, OH or SH, R is STR2 and X is STR3 in which R' is H or CH3 or STR4 in which R and R' are as previously defined, provided when Y is NH2, R' must be CH3 and when Y is OH, R' must be OH.