1166855-25-9

Basic information

• Product Name: methyl 1-(4-(((2,4-diaminopteridin-6-yl)methyl)(2-ethoxy-2-oxoethyl)amino)benzoyl)piperidine-4-carboxylate
• CAS NO: 1166855-25-9
• Molecular Weight: 522.564
• Mol File: 1166855-25-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 1-(4-(((2,4-diaminopteridin-6-yl)methyl)(2-ethoxy-2-oxoethyl)amino)benzoyl)piperidine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 1-(4-(((2,4-diaminopteridin-6-yl)methyl)(2-ethoxy-2-oxoethyl)amino)benzoyl)piperidine-4-carboxylate(1166855-25-9)
• EPA Substance Registry System: methyl 1-(4-(((2,4-diaminopteridin-6-yl)methyl)(2-ethoxy-2-oxoethyl)amino)benzoyl)piperidine-4-carboxylate(1166855-25-9)

Safety Data

• Hazardous Substances Data: 1166855-25-9(Hazardous Substances Data)

Upstream product

• 1017621-79-2 methyl 1-(4-aminobenzoyl)piperidine-4-carboxylate 
• 349613-86-1 methyl 1-(4-nitrobenzoyl)piperidine-4-carboxylate 
• 2971-79-1 isonipecotic acid methyl ester 
• 1311958-10-7 methyl 1-(4-(2-ethoxy-2-oxoethylamino)benzoyl)piperidine-4-carboxylate 
• 52853-40-4 6-bromomethyl-2,4-diaminopteridine hydrobromide 
• 122-04-3 4-nitro-benzoyl chloride 

Relevant articles and documents

Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors

The upregulation of pteridine reductase (PTR1) is a major contributor to antifolate drug resistance in Leishmania spp., as it provides a salvage pathway that bypasses dihydrofolate reductase (DHFR) inhibition. The structure-based optimization of the PTR1 inhibitor methyl-1-[4-(2,4-diaminopteridin-6- ylmethylamino)benzoyl]piperidine-4-carboxylate (1) led to the synthesis of a focused compound library which showed significantly improved selectivity for the parasite's folate-dependent enzyme. When used in combination with pyrimethamine, a DHFR inhibitor, a synergistic effect was observed for compound 5b. This work represents a step forward in the identification of effective antileishmania agents.