2-(bromomethyl)-1,3-dichloro-5-methoxybenzene

Base Information

• Chemical Name: 2-(bromomethyl)-1,3-dichloro-5-methoxybenzene
• CAS No.: 94278-70-3
• Molecular Formula: C8H7BrCl2O
• Molecular Weight: 269.953
• Hs Code.: 2916399090
• Mol file: 94278-70-3.mol

Synonyms:2-bromomethyl-1,3-dichloro-5-methoxy-benzene;2,6-dichloro-4-methoxybenzyl bromide;

Chemical Property of 2-(bromomethyl)-1,3-dichloro-5-methoxybenzene

Chemical Property:

• PSA: 9.23000
• LogP: 3.89690

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(bromomethyl)-1,3-dichloro-5-methoxybenzene

There total 6 articles about 2-(bromomethyl)-1,3-dichloro-5-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dichloro-4-methoxy-benzaldehyde (82772-93-8) → 2-(bromomethyl)-1,3-dichloro-5-methoxybenzene (94278-70-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 2 h / 7 °C

2: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C

With sodium tetrahydroborate; phosphorus tribromide; In tetrahydrofuran; ethanol;

Reference yield:

2,6-dichloro-4-hydroxybenzaldehyde (60964-09-2) → 2-(bromomethyl)-1,3-dichloro-5-methoxybenzene (94278-70-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2: sodium tetrahydroborate / ethanol / 2 h / 7 °C

3: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C

With sodium tetrahydroborate; phosphorus tribromide; potassium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

methyl 2,6-dichloro-4-methoxybenzoate (94278-65-6) → 2-(bromomethyl)-1,3-dichloro-5-methoxybenzene (94278-70-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / LiAlH₄ / diethyl ether / 3 h / 0 °C

2: 30percent aq. HBr, AcOH / 1.5 h / Ambient temperature

With lithium aluminium tetrahydride; hydrogen bromide; acetic acid; In diethyl ether;

DOI:10.1021/jo00203a032

upstream raw materials:

methyl 2,6-dichloro-4-methoxybenzoate

2,6-dichloro-4-hydroxybenzaldehyde

2,6-dichloro-4-methoxy-benzaldehyde

4-(benzyloxy)-2,6-dichlorobenzaldehyde

Downstream raw materials:

2,6-dichloro-4-methoxy-benzylamine hydrochloride

3-[2,6-Dichloro-4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

3,5-Dichloro-N-isobutyl-4-[2-oxo-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-benzamide

C₂₇H₂₄Cl₂F₃N₃O₅S

Refernces

• 1、 -. "CYCLOHEXYLPYRAZOLE-LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1". . . Retrieved 2009/05/29.
• 2、 -. "SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1". . . Retrieved 2008/06/13.