2-Chloro-3-(dimethoxymethyl)-6-methoxypyridine

Base Information

• Chemical Name: 2-Chloro-3-(dimethoxymethyl)-6-methoxypyridine
• CAS No.: 95652-79-2
• Molecular Formula: C9H12ClNO3
• Molecular Weight: 217.652
• DSSTox Substance ID: DTXSID10538920
• Wikidata: Q82414494
• Mol file: 95652-79-2.mol

Synonyms:95652-79-2;2-Chloro-3-(dimethoxymethyl)-6-methoxypyridine;DTXSID10538920

Chemical Property of 2-Chloro-3-(dimethoxymethyl)-6-methoxypyridine

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 217.0505709
• Heavy Atom Count: 14
• Complexity: 166

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=NC(=C(C=C1)C(OC)OC)Cl

Technology Process of 2-Chloro-3-(dimethoxymethyl)-6-methoxypyridine

There total 3 articles about 2-Chloro-3-(dimethoxymethyl)-6-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

methanol (67-56-1) + 2-chloro-3-(trichloromethyl)-pyridine (72648-12-5) → 2,6-dimethoxypyridine-3-carboxaldehyde (58819-72-0) + 2-chloro-6-methoxy-3-pyridine-carboxaldehyde (95652-80-5) + 2-chloro-3-(dimethoxymethyl)-6-methoxypyridine (95652-79-2)

Guidance literature:

With sodium;

DOI:10.1016/S0040-4039(01)91414-5

Reference yield: 59.0%

methanol (67-56-1) + 2-chloro-3-(trichloromethyl)-pyridine (72648-12-5) → 2,6-dimethoxypyridine-3-carboxaldehyde (58819-72-0) + 2-chloro-3-(dimethoxymethyl)-6-methoxypyridine (95652-79-2)

Guidance literature:

With sodium; for 6h; Heating;

Reference yield: 22.0%

methanol (67-56-1) + 2-chloro-3-(trichloromethyl)-pyridine (72648-12-5) → 2-chloro-3-dichloromethyl-6-methoxypyridine (121643-43-4) + 2-chloro-3-(dimethoxymethyl)-6-methoxypyridine (95652-79-2)

Guidance literature:

With sodium; for 2h; Heating;

upstream raw materials:

methanol

2-chloro-3-(trichloromethyl)-pyridine

Refernces

• 1、 Dainter, Ronald S.,Suschitzky, Hans,Wakefield, Basil J.,Hughes, Nigel,Nelson, Anthony J.. "ABNORMAL NUCLEOPHILIC SUBSTITUTION OF 3-TRICHLOROMETHYLPYRIDINES BY METHOXIDE". . p. 5693 - 5696. Retrieved 2007/10/02.