3-METHOXYPHENETHYL BROMIDE

Base Information

• Chemical Name: 3-METHOXYPHENETHYL BROMIDE
• CAS No.: 2146-61-4
• Molecular Formula: C9H11BrO
• Molecular Weight: 215.09
• Hs Code.: 2909309090
• Mol file: 2146-61-4.mol

Synonyms:Anisole, m-(2-bromoethyl)-;1-Bromo-2-(3-methoxyphenyl)ethane;1-(2-Bromo-ethyl)-3-methoxy-benzene;3-Methoxy-1-(2-bromoethyl)benzene;

Chemical Property of 3-METHOXYPHENETHYL BROMIDE

Chemical Property:

• Appearance/Colour: COLORLESS TO YELLOW LIQUID
• Vapor Pressure: 0.0298mmHg at 25°C
• Refractive Index: n20/D 1.5593(lit.)
• Boiling Point: 253 °C at 760 mmHg
• Flash Point: 100.2 °C
• PSA: 9.23000
• Density: 1.349 g/cm³
• LogP: 2.63260

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Methoxyphenethyl bromide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 22-34-52/53
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 3-METHOXYPHENETHYL BROMIDE

There total 7 articles about 3-METHOXYPHENETHYL BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(3-methoxyphenyl)-ethanol (5020-41-7) → 3-methoxyphenethyl bromide (2146-61-4)

Guidance literature:

With bromine; triphenylphosphine; In N,N-dimethyl-formamide; at 90 ℃; for 25h;

Reference yield: 76.0%

2-(3-methoxyphenyl)-ethanol (5020-41-7) → 3-methoxyphenethyl bromide (2146-61-4) + 2-(3-hydroxyphenyl)ethyl bromide (52059-50-4)

Guidance literature:

With hydrogen bromide; cetyltributylphosphonium bromide; for 1.5h; Heating;

DOI:10.1016/S0968-0896(00)00110-3

Reference yield:

m-methoxyphenylacetic acid (1798-09-0) → 3-methoxyphenethyl bromide (2146-61-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / LAH / tetrahydrofuran / 3 h / Heating

2: 5 percent / tributylhexadecylphosphonium bromide; 47 percent HBr / 1.5 h / Heating

With lithium aluminium tetrahydride; hydrogen bromide; cetyltributylphosphonium bromide; In tetrahydrofuran; 1: Reduction / 2: Substitution;

DOI:10.1016/S0968-0896(00)00110-3

upstream raw materials:

2-(3-methoxyphenyl)-ethanol

m-methoxyphenylacetic acid

(3-methoxyphenyl)magnesium bromide

ETHYL 3-METHOXYPHENYLACETATE

Downstream raw materials:

(3-methoxy-phenethyl)-malonic acid diethyl ester

1-(3-methoxy-phenethyl)-4-phenyl-piperidine-4-carboxylic acid ethyl ester

3-(2-bromo-ethyl)-4-chloro-anisole

2-(m-Anisyl)ethylhydrazin

Refernces

• 1、 -. "Preparation method 3 - methoxyethyl bromide". Paragraph 0020-0040. . Retrieved 2021/11/10.
• 2、 -. "SUBSTITUTED BENZENE COMPOUNDS". Paragraph 0981; 0982. . Retrieved 2015/02/02.