3-(2-bromo-ethyl)-4-chloro-anisole

Base Information

• Chemical Name: 3-(2-bromo-ethyl)-4-chloro-anisole
• CAS No.: 90350-30-4
• Molecular Formula: C₉H₁₀BrClO
• Molecular Weight: 249.535
• Mol file: 90350-30-4.mol

Synonyms:

Chemical Property of 3-(2-bromo-ethyl)-4-chloro-anisole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-bromo-ethyl)-4-chloro-anisole

There total 7 articles about 3-(2-bromo-ethyl)-4-chloro-anisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxyphenethyl bromide (2146-61-4) → 3-(2-bromo-ethyl)-4-chloro-anisole (90350-30-4)

Guidance literature:

With tetrachloromethane; sulfuryl dichloride;

DOI:10.1021/ja01136a037

Reference yield:

2-(bromomethyl)-1-chloro-4-methoxybenzene (3771-13-9) → 3-(2-bromo-ethyl)-4-chloro-anisole (90350-30-4)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol

2: NaOH / methanol

4: (i) LiAlH₄, Et₂O, (ii) PBr₃

With sodium hydroxide; In methanol; ethanol;

DOI:10.1016/S0040-4020(01)99309-3

Reference yield:

(2-chloro-5-methoxyphenyl)methanol (101252-66-8) → 3-(2-bromo-ethyl)-4-chloro-anisole (90350-30-4)

Guidance literature:

Multi-step reaction with 5 steps

1: PBr₃ / diethyl ether

2: ethanol

3: NaOH / methanol

5: (i) LiAlH₄, Et₂O, (ii) PBr₃

With sodium hydroxide; phosphorus tribromide; In methanol; diethyl ether; ethanol;

DOI:10.1016/S0040-4020(01)99309-3

upstream raw materials:

3-methoxyphenethyl bromide

(2-chloro-5-methoxy-phenyl)-acetic acid methyl ester

2-(bromomethyl)-1-chloro-4-methoxybenzene

(2-chloro-5-methoxyphenyl)methanol