N-Acetyl Folic Acid-d4

Base Information

• Chemical Name: N-Acetyl Folic Acid-d4
• CAS No.: 461426-36-8
• Molecular Formula: C21H17D4N7O7
• Molecular Weight: 487.458787112
• Mol file: 461426-36-8.mol

Synonyms:N-{[4-({[2-(Acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-(3,3,4,4-2H4)glutamic acid;

Chemical Property of N-Acetyl Folic Acid-d4

Chemical Property:

• PSA: 220.11000
• LogP: 1.85710
• Solubility.: Ethyl Acetate, Methanol

Purity/Quality:

99% ^*data from raw suppliers

N-Acetyl Folic Acid-d4 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Acetyl Folic Acid-d4

There total 9 articles about N-Acetyl Folic Acid-d4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

2-acetylamino-4-hydroxy-6-formylpteridine (29769-49-1) + [2H4]p-aminobenzoylglutamic acid (461426-34-6) → N2-acetyl[2H4]folic acid (461426-36-8)

Guidance literature:

With dimethylamine borane; acetic acid; at 60 ℃; for 0.333333h;

DOI:10.1021/jf025571k

Reference yield:

L-glutamic acid dimethyl ester (6525-53-7,16422-27-8,40149-68-6) → N2-acetyl[2H4]folic acid (461426-36-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / tetrahydrofuran / 0.5 h / 20 °C

1.2: diisopropylethylamine / tetrahydrofuran / 4 h / 20 °C

2.1: 76 percent / aq. NaOH / methanol / 1.75 h / 20 °C

3.1: 35 percent / glacial acetic acid; dimethylaminoborane / 0.33 h / 60 °C

With dimethylamine borane; sodium hydroxide; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;

DOI:10.1021/jf025571k

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → N2-acetyl[2H4]folic acid (461426-36-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 58.1 percent / deuterium oxide; Pd/C / 2 h / 200 °C

2.1: 2 h / 20 °C

3.1: dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / tetrahydrofuran / 0.5 h / 20 °C

3.2: diisopropylethylamine / tetrahydrofuran / 4 h / 20 °C

4.1: 76 percent / aq. NaOH / methanol / 1.75 h / 20 °C

5.1: 35 percent / glacial acetic acid; dimethylaminoborane / 0.33 h / 60 °C

With dimethylamine borane; sodium hydroxide; palladium on activated charcoal; water-d2; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;

DOI:10.1021/jf025571k

upstream raw materials:

2-acetylamino-4-hydroxy-6-formylpteridine

[2H₄]p-aminobenzoylglutamic acid

2,4-diamino-6-formylpteridine dimethyl acetal

L-glutamic acid dimethyl ester

Downstream raw materials:

<2',3',5',6'-2H4>folic acid

Refernces