methyl-pyridin-4-ylmethyl-amine

Base Information

• Chemical Name: methyl-pyridin-4-ylmethyl-amine
• CAS No.: 27854-96-2
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 2933399090
• Mol file: 27854-96-2.mol

Synonyms:(S)-1-(4-PYRIDINYL)ETHYLAMINE; (S)-1-(Pyridin-4-yl)ethanamine; (1S)-1-(4-PYRIDYL)ETHYLAMINE;

Chemical Property of methyl-pyridin-4-ylmethyl-amine

Chemical Property:

• Boiling Point: 221.1±15.0 °C(Predicted)
• PKA: 8.28±0.29(Predicted)
• PSA: 38.91000
• Density: 1.018±0.06 g/cm3(Predicted)
• LogP: 1.80160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

(1S)-1-(4-Pyridyl)ethylamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl-pyridin-4-ylmethyl-amine

There total 3 articles about methyl-pyridin-4-ylmethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (4-pyridyl) ketone (1122-54-9) + 1,5-diaminopentane (462-94-2) → 2,3,4,5-tetrahydropyridine (505-18-0) + (S)-1-(4-pyridyl)ethylamine (27854-96-2)

Guidance literature:

With spuC gene from Pseudomonas putida; In dimethyl sulfoxide; at 40 ℃; for 24h; pH=9; Reagent/catalyst; enantioselective reaction; Enzymatic reaction;

DOI:10.1039/c6gc02102f

Reference yield:

methyl (4-pyridyl) ketone (1122-54-9) + N-butylamine (109-73-9,85404-21-3) → (S)-1-(4-pyridyl)ethylamine (27854-96-2) + butan-1-ol (71-36-3)

Guidance literature:

With pyridoxal 5'-phosphate; β-nicotinamide adenine dinucleotide hydrate; In dimethyl sulfoxide; at 37 ℃; for 16h; pH=9; Reagent/catalyst; Green chemistry; Enzymatic reaction;

DOI:10.1016/j.cattod.2017.01.025

Reference yield:

methyl (4-pyridyl) ketone (1122-54-9) → (R)-1-(pyridin-4-yl)ethan-1-amine (45682-36-8) + (S)-1-(4-pyridyl)ethylamine (27854-96-2)

Guidance literature:

With pyridoxal 5'-phosphate; isopropylamine; In dimethyl sulfoxide; at 30 ℃; for 24h; pH=7.5; Reagent/catalyst; Enzymatic reaction;

DOI:10.1021/op4003104

upstream raw materials:

methyl (4-pyridyl) ketone

1,5-diaminopentane

N-butylamine

Refernces

• 1、 Galman, James L.,Slabu, Iustina,Weise, Nicholas J.,Iglesias, Cesar,Parmeggiani, Fabio,Lloyd, Richard C.,Turner, Nicholas J.. "Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases". supporting information. p. 361 - 366. Retrieved 2017/08/14.