(+)-Camphor

Base Information

• Chemical Name: (+)-Camphor
• CAS No.: 21368-68-3
• Molecular Formula: C₁₀H₁₆O
• Molecular Weight: 152.236
• Hs Code.: 29142910
• ChEMBL ID: CHEMBL1316134
• Metabolomics Workbench ID: 75127
• Nikkaji Number: J2.997.715A
• Mol file: 21368-68-3.mol

Synonyms:(+)-Camphor;d-2-Bornanone;(1R)-Camphor;D-(+)-Camphor;DL-Camphor;MFCD00064149;(1R)-(+)-Camphor;(+)-Campher;(1R)(+)camphor;CHEMBL1316134;SCHEMBL13248606;DSSYKIVIOFKYAU-MHPPCMCBSA-N;AKOS030504171;NCGC00094605-01;NCGC00094605-02;C00808

Chemical Property of (+)-Camphor

Chemical Property:

• Appearance/Colour: White powder with a penetrating, aromatic odor.
• Vapor Pressure: 4 mm Hg ( 70 °C)
• Melting Point: 175oC
• Refractive Index: 1.485
• Boiling Point: 204oC
• Flash Point: 64oC
• PSA: 17.07000
• Density: 0.992
• LogP: 2.40170
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 152.120115130
• Heavy Atom Count: 11
• Complexity: 217

Purity/Quality:

99% ^*data from raw suppliers

Camphor (dl) primary reference standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R22:
• Hazard Codes: F,Xn
• Statements: 11-22-36/37/38-36-20/21/22
• Safety Statements: 16-26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(C2CCC1(C(=O)C2)C)C
• Isomeric SMILES: C[C@@]12CCC(C1(C)C)CC2=O

Technology Process of (+)-Camphor

There total 6 articles about (+)-Camphor which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

C12H20S2 → Campher (76-22-2,464-48-2,464-49-3,21368-68-3,68546-28-1)

Guidance literature:

With 2,4,4,6-Tetrabromo-2,5-cyclohexadien-1-one; dihydrogen peroxide; In water; acetonitrile; at 20 ℃; for 7h;

Reference yield: 69.0%

(1S,4S)-3-bromo-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one (76-29-9,1925-58-2,10293-06-8,27799-07-1,55057-87-9,64474-54-0,67337-12-6,107870-25-7) → Campher (76-22-2,464-48-2,464-49-3,21368-68-3,68546-28-1)

Guidance literature:

With water; zinc; In acetonitrile; at 80 ℃; for 11h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.joc.9b02026

Reference yield:

(+)-borneol (124-76-5,464-43-7,464-45-9,507-70-0,6627-72-1,10334-13-1,10385-78-1,16725-71-6,24393-70-2) → Campher (76-22-2,464-48-2,464-49-3,21368-68-3,68546-28-1)

Guidance literature:

With oxygen; In water; at 80 ℃; for 24h; under 759.826 Torr; Green chemistry;

DOI:10.1002/cctc.201501229

upstream raw materials:

(+)-borneol

(1S,4S)-3-bromo-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one

d-borneol

1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-one

Downstream raw materials:

C₁₀H₁₉N

5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrazole-3-carboxamide

p-Anisylisoborneol

2-Hydroxy-1,2-diphenyl-ethanesulfonic acid [1,7,7-trimethyl-bicyclo[2.2.1]hept-(2E)-ylidene]-amide

Refernces

• 1、 Xia, Aiyou,Xie, Xin,Hu, Xiaoping,Xu, Wei,Liu, Yuanhong. "Dehalogenative Deuteration of Unactivated Alkyl Halides Using D2O as the Deuterium Source". . p. 13841 - 13857. Retrieved 2019/10/17.
• 2、 Ganguly, Nemai C.,Nayek, Subhasis,Barik, Sujoy Kumar. "Aqueous hydrogen peroxide and 2,4,4,6-tetrabromo-2,5-cyclohexadienone catalyst: An efficient mild ecofriendly cleaving reagent of thioacetals and thioketals". scheme or table. p. 251 - 256. Retrieved 2012/03/11.