Methyl 5-methylpicolinate

Base Information

• Chemical Name: Methyl 5-methylpicolinate
• CAS No.: 29681-38-7
• Molecular Formula: C8H9 N O2
• Molecular Weight: 151.165
• Hs Code.: 2933399090
• NSC Number: 109152
• DSSTox Substance ID: DTXSID80296409
• Nikkaji Number: J1.051.320K
• Wikidata: Q72493041
• Mol file: 29681-38-7.mol

Synonyms:Methyl 5-methylpicolinate;29681-38-7;methyl 5-methylpyridine-2-carboxylate;5-METHYLPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER;2-Pyridinecarboxylic acid, 5-methyl-, methyl ester;MFCD11040648;Methyl 5-methyl-2-pyridinecarboxylate;260998-85-4;methyl5-methylpicolinate;2-Pyridinecarboxylicacid,5-methyl-,methylester(9CI);NSC109152;5-Methyl-2-pyridinecarboxylic acid methyl ester;SCHEMBL82621;DTXSID80296409;GLXLMXAFURBIEZ-UHFFFAOYSA-N;AKOS006281403;CS-W006118;FS-3454;NSC-109152;AM803652;SY046550;FT-0745041;A876406;J-401000

Chemical Property of Methyl 5-methylpicolinate

Chemical Property:

• Vapor Pressure: 0.0182mmHg at 25°C
• Melting Point: 54-55℃
• Boiling Point: 253.5°Cat760mmHg
• PKA: 1.98±0.10(Predicted)
• Flash Point: 107.1°C
• PSA: 39.19000
• Density: 1.104g/cm³
• LogP: 1.17660
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 151.063328530
• Heavy Atom Count: 11
• Complexity: 147

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl5-methylpicolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(C=C1)C(=O)OC

Technology Process of Methyl 5-methylpicolinate

There total 13 articles about Methyl 5-methylpicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ methyl 5-methylpyridine-2-carboxylate (29681-38-7)

Guidance literature:

With tetrabutylammonium triphenyldifluorosilicate; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield: 59.0%

methanol (67-56-1) + 2-carboxy-5-methylpyridine (4434-13-3) → methyl 5-methylpyridine-2-carboxylate (29681-38-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 - 70 ℃;

Reference yield: 50.0%

methanol (67-56-1) + 2,5-dimethylpyridine (589-93-5) → methyl 5-methylpyridine-2-carboxylate (29681-38-7)

Guidance literature:

2,5-dimethylpyridine; With selenium(IV) oxide; In pyridine; Reflux;

methanol; With sulfuric acid; for 5h; Reflux;

upstream raw materials:

methanol

methyl pyridine-2-carboxylate

diazomethane

2-carboxy-5-methylpyridine

Downstream raw materials:

methyl 5-((3-ethylphenoxy)methyl)picolinate

5-((3-ethylphenoxy)methyl)picolinic acid

methyl 5-(m-tolyloxymethyl)picolinate

5-(m-tolyloxymethyl)picolinic acid

Refernces

• 1、 -. "Synthesis of Esters by Functionalisation of CO2". Paragraph 0129. . Retrieved 2017/09/06.
• 2、 -. "Substituted benzoxazoles". Paragraph 0509. . Retrieved 2016/10/10.