lithium phenyl-2,4,6-trimethylbenzoylphosphinate

Base Information

• Chemical Name: lithium phenyl-2,4,6-trimethylbenzoylphosphinate
• CAS No.: 85073-19-4
• Molecular Formula: C16H16LiO3P
• Molecular Weight: 294.216
• Hs Code.: 2931499090
• Mol file: 85073-19-4.mol

Synonyms:lithium phenyl-2,4,6-trimethylbenzoylphosphinate

Chemical Property of lithium phenyl-2,4,6-trimethylbenzoylphosphinate

Chemical Property:

• PSA: 67.01000
• LogP: 3.78610
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

LAP ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) is a water soluble, cytocompatible, Type I photoinitiator for use in the polymerization of hydrogels or other polymeric materials. This photoinitator is preferred over Irgacure 2959 for biological applications due to its increased water solubility, increased polymerization rates with 365 nm light, and absorbance at 400 nm allowing for polymerization with visible light. The improved polymerization kinetics enable cell encapsualation at reduced initiator concentration and longer wavelength light, which has been shown to reduce initiator toxicity and increase cell viability.

Technology Process of lithium phenyl-2,4,6-trimethylbenzoylphosphinate

There total 5 articles about lithium phenyl-2,4,6-trimethylbenzoylphosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

phenylphosphonous acid dimethyl ester (2946-61-4) + mesitylene-2-carboxylic acid chloride (938-18-1) → lithium (2,4,6-trimethylbenzoyl)phenylphosphine oxide (85073-19-4)

Guidance literature:

phenylphosphonous acid dimethyl ester; mesitylene-2-carboxylic acid chloride; Inert atmosphere;

With lithium bromide; In butanone; Inert atmosphere;

DOI:10.1002/anie.201611446

Reference yield:

2,4,6-trimethylbenzoylphenylphosphinic acid ethyl ester (84434-11-7) → lithium (2,4,6-trimethylbenzoyl)phenylphosphine oxide (85073-19-4)

Guidance literature:

With lithium iodide; In butanone; at 60 ℃; for 24h;

Reference yield:

2,4,6-trimethylbenzoyl-methoxy-phenylphosphine oxide (75994-74-0) → lithium (2,4,6-trimethylbenzoyl)phenylphosphine oxide (85073-19-4)

Guidance literature:

With lithium bromide; In butanone; at 50 ℃; for 1h;

DOI:10.1002/anie.201915100

upstream raw materials:

phenylphosphonous acid dimethyl ester

mesitylene-2-carboxylic acid chloride

2,4,6-trimethylbenzoyl-methoxy-phenylphosphine oxide

2,4,6-trimethylbenzoylphenylphosphinic acid ethyl ester

Refernces

• 1、 Bertz, Andreas,Ehlers, Jan-Eric,W?hl-Bruhn, Stefanie,Bunjes, Heike,Gericke, Karl-Heinz,Menzel, Henning. "Mobility of green fluorescent protein in hydrogel-based drug-delivery systems studied by anisotropy and fluorescence recovery after photobleaching". . p. 215 - 226. Retrieved 2013.
• 2、 Levalley, Paige J.,Ovadia, Elisa M.,Bresette, Christopher A.,Sawicki, Lisa A.,Maverakis, Emanual,Bai, Shi,Kloxin, April M.. "Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications". . p. 6923 - 6926. Retrieved 2018.
• 3、 Mendes, Eduardo,Oldenhof, Sander,Wang, Yiming,Zhang, Kai,van Esch, Jan H.. "Spatial Manipulation and Integration of Supramolecular Filaments on Hydrogel Substrates towards Advanced Soft Devices". supporting information. p. 8601 - 8607. Retrieved 2020/03/30.
• 4、 -. "Preparation method, raw material, product and application of photo-crosslinking hydrogel material". Paragraph 0900-0902. . Retrieved 2019/06/07.