5-Bromo-3-cyclopropyl-1-methylindazole

Base Information

• Chemical Name: 5-Bromo-3-cyclopropyl-1-methylindazole
• CAS No.: 1311197-79-1
• Molecular Formula: C₁₁H₁₁BrN₂
• Molecular Weight: 251.126
• Hs Code.: 2933990090
• Mol file: 1311197-79-1.mol

Synonyms:5-Bromo-3-cyclopropyl-1-methylindazole;5-BroMo-3-cyclopropyl-1-Methyl-1H-indazole

Chemical Property of 5-Bromo-3-cyclopropyl-1-methylindazole

Chemical Property:

• PSA: 17.82000
• LogP: 3.21320
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-3-cyclopropyl-1-methylindazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-3-cyclopropyl-1-methylindazole

There total 3 articles about 5-Bromo-3-cyclopropyl-1-methylindazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

(5-bromo-2-fluorophenyl)(cyclopropyl)methanone (1222368-75-3) + methylhydrazine (60-34-4) → 5-bromo-3-cyclopropyl-1-methyl-1H-indazole (1311197-79-1)

Guidance literature:

With potassium carbonate; copper(II) oxide; In water; N,N-dimethyl-formamide; at 110 ℃; for 16h;

DOI:10.1021/acsmedchemlett.6b00075

Reference yield:

5-bromo-2-fluorobenzaldehyde (93777-26-5) → 5-bromo-3-cyclopropyl-1-methyl-1H-indazole (1311197-79-1)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 3 h / 0 - 20 °C

2: manganese(IV) oxide / dichloromethane / 5 h / 40 °C

3: potassium carbonate; copper(II) oxide / N,N-dimethyl-formamide; water / 16 h / 110 °C

With manganese(IV) oxide; potassium carbonate; copper(II) oxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

(5-bromo-2-fluorophenyl)(cyclopropyl)methanol → 5-bromo-3-cyclopropyl-1-methyl-1H-indazole (1311197-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: manganese(IV) oxide / dichloromethane / 5 h / 40 °C

2: potassium carbonate; copper(II) oxide / N,N-dimethyl-formamide; water / 16 h / 110 °C

With manganese(IV) oxide; potassium carbonate; copper(II) oxide; In dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

(5-bromo-2-fluorophenyl)(cyclopropyl)methanone

methylhydrazine

5-bromo-2-fluorobenzaldehyde

Refernces

• 1、 -. "THERAPEUTIC COMPOUNDS AND USES THEREOF". Page/Page column 141. . Retrieved 2016/05/02.