Fluorene, 2-chloro-7-nitro-

Base Information

• Chemical Name: Fluorene, 2-chloro-7-nitro-
• CAS No.: 6939-05-5
• Molecular Formula: C13H8 Cl N O2
• Molecular Weight: 245.66
• Hs Code.: 2904909090
• NSC Number: 56747
• DSSTox Substance ID: DTXSID00219498
• Nikkaji Number: J308.966E
• Wikidata: Q83096439
• ChEMBL ID: CHEMBL164710
• Mol file: 6939-05-5.mol

Synonyms:2-Chloro-7-nitrofluorene;2-Chloro-7-nitro-9H-fluorene;FLUORENE, 2-CHLORO-7-NITRO-;6939-05-5;NSC 56747;BRN 1979585;NSC56747;2-chlor-7-nitrofluorene;CHEMBL164710;DTXSID00219498;2-Chloro-7-nitro-9H-fluorene #;NSC-56747;AKOS024342529;LS-69250;4-05-00-02151 (Beilstein Handbook Reference)

Chemical Property of Fluorene, 2-chloro-7-nitro-

Chemical Property:

• Vapor Pressure: 1.39E-06mmHg at 25°C
• Boiling Point: 410.9°C at 760 mmHg
• Flash Point: 202.3°C
• PSA: 45.82000
• Density: 1.427g/cm³
• LogP: 4.34260
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 245.0243562
• Heavy Atom Count: 17
• Complexity: 317

Purity/Quality:

99%min ^*data from raw suppliers

2-Chloro-7-nitro-9H-fluorene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2=C(C=CC(=C2)[N+](=O)[O-])C3=C1C=C(C=C3)Cl
• Uses: 2-Chloro-7-nitro-9H-fluorene can be employed for the calculation of solvent dipolarity and polarizability properties.

Technology Process of Fluorene, 2-chloro-7-nitro-

There total 8 articles about Fluorene, 2-chloro-7-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitro-9H-fluorene (607-57-8) → 7-chloro-2-nitrofluorene (6939-05-5)

Guidance literature:

With iodine; chlorine; chlorobenzene; at 100 ℃;

DOI:10.1021/ja01152a524

Reference yield:

2-chloro-9H-fluorene (2523-44-6) → 7-chloro-2-nitrofluorene (6939-05-5)

Guidance literature:

With nitric acid; acetic acid; at 70 - 80 ℃;

Reference yield:

4-nitro-4'-chloro-[1,1'-biphen-2-yl]methanol (480462-57-5) → 7-chloro-2-nitrofluorene (6939-05-5)

Guidance literature:

With PPA; at 110 ℃;

DOI:10.1016/j.bmcl.2005.08.003

upstream raw materials:

2-nitro-9H-fluorene

2-chloro-9H-fluorene

nitric acid

acetic acid

Downstream raw materials:

N-(7-chloro-fluoren-2-yl)-acetamide

2-amino-7-chloro-fluoren-9-ol

2-amino-7-chloro-fluoren-9-one

2-chloro-7-nitro-fluoren-9-one

Refernces

• 1、 Greenfield, Alexander,Grosanu, Cristina,Dunlop, John,McIlvain, Beal,Carrick, Tikva,Jow, Brian,Lu, Qiang,Kowal, Dianne,Williams, John,Butera, John. "Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2". . p. 4985 - 4988. Retrieved 2007/10/03.