(2S)-2-Methyl-2-PyrrolidinecarboxaMide

Base Information

• Chemical Name: (2S)-2-Methyl-2-PyrrolidinecarboxaMide
• CAS No.: 132235-43-9
• Molecular Formula: C6H12N2O
• Molecular Weight: 128.174
• Mol file: 132235-43-9.mol

Synonyms:(2S)-2-Methyl-2-PyrrolidinecarboxaMide;(S)-2-Methylpyrrolidine-2-carboxaMide

Chemical Property of (2S)-2-Methyl-2-PyrrolidinecarboxaMide

Chemical Property:

• Melting Point: 45-46 °C
• Boiling Point: 286.4±29.0 °C(Predicted)
• PKA: 16.21±0.20(Predicted)
• PSA: 55.12000
• Density: 1.054±0.06 g/cm3(Predicted)
• LogP: 0.64290
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-Methylpyrrolidine-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S)-2-Methyl-2-PyrrolidinecarboxaMide

There total 16 articles about (2S)-2-Methyl-2-PyrrolidinecarboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

benzyl (S)-2-carbamoyl-2-methylpyrrolidine-1-carboxylate (1031890-09-1) → (S)-2-methylpyrrolidine-2-carboxylic acid amide (132235-43-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 760 Torr;

Reference yield: 76.0%

(1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-pyrrolidine carboxamide (132235-40-6) → (S)-2-methylpyrrolidine-2-carboxylic acid amide (132235-43-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 48h; under 760 Torr;

Reference yield: 51.0%

DL-(α-methyl)proline amide (848488-83-5) → (S)-2-methylpyrrolidine-2-carboxylic acid amide (132235-43-9) + (2R)-2-methyl-2-pyrrolidinecarboxamide (132235-42-8) + (R)-2-Methyl-1-azacyclopentan-2-carbonsaeure (63399-77-9)

Guidance literature:

With Mycobacterium neoaurum ATCC 25795 amidase; acetic acid; In water; at 37 ℃; for 70h; pH=8.5; optical yield given as %ee; stereoselective reaction; Resolution of racemate; Enzymatic reaction;

DOI:10.1002/chem.200900688

upstream raw materials:

benzyl (S)-2-carbamoyl-2-methylpyrrolidine-1-carboxylate

(1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-pyrrolidine carboxamide

3,4-dihydro-5-methyl-2H-pyrrole 1-oxide

(S)-1-((benzyloxy)carbonyl)-2-methylpyrrolidine-2-carboxylic acid

Downstream raw materials:

(S)-2-methyl-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({5-[2-(2,6-dichloro-benzyl)-pyrimidin-4-yl]-4-methyl-thiazol-2-yl}-amide)

(S)-2-methyl-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({5-[2-(2-fluoro-phenyl)-pyrimidin-4-yl]-4-methyl-thiazol-2-yl}-amide)

(S)-2-methyl-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-{[5-(2-benzyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]-amide}

(S)-2-methyl-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-{[5-(3-tert-butyl-phenyl)-4-methyl-thiazol-2-yl]-amide}

Refernces

• 1、 -. "METHOD FOR PRODUCING OPTICALLY ACTIVE ALPHA-SUBSTITUTED PROLINE". Paragraph 0225. . Retrieved 2014/05/06.
• 2、 -. "Organic Compounds". Page/Page column 38. . Retrieved 2009/07/10.