NA

Base Information

• Chemical Name: NA
• CAS No.: 1262858-69-4
• Molecular Formula: C11H13BrN2O
• Molecular Weight: 269.141
• Mol file: 1262858-69-4.mol

Synonyms:(RS)-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine;(RS)-5-(3-bromo-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine;

Chemical Property of NA

Chemical Property:

• PSA: 47.61000
• LogP: 2.18760

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of NA

There total 11 articles about NA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(RS)-3-(3-Bromo-phenyl)-5-methoxy-3-methyl-3,6-dihydro-2H [1,4]oxazine (1266784-81-9) → rac-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine (1262858-69-4)

Guidance literature:

With ammonium chloride; In methanol; at 100 ℃; Sealed tube;

Reference yield: 53.0%

rac-5-(3-bromophenyl)-5-methylmorpholin-3-one (1262858-67-2) → rac-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine (1262858-69-4)

Guidance literature:

rac-5-(3-bromophenyl)-5-methylmorpholin-3-one; With trimethoxonium tetrafluoroborate; In dichloromethane; at 20 ℃;

With ammonium chloride; In methanol; at 100 ℃; for 16h;

Reference yield: 53.0%

rac-5-(3-bromophenyl)-5-methylmorpholin-3-one (1262858-67-2) + trimethoxonium tetrafluoroborate (420-37-1) → rac-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine (1262858-69-4)

Guidance literature:

rac-5-(3-bromophenyl)-5-methylmorpholin-3-one; trimethoxonium tetrafluoroborate; In dichloromethane; at 20 ℃; Inert atmosphere;

With ammonium chloride; In methanol; at 100 ℃; for 16h;

With ammonia; In methanol;

upstream raw materials:

(RS)-2-amino-2-(3-bromo-phenyl)-propan-1-ol

rac-N-[1-(3-bromophenyl)-2-hydroxy-1-methylethyl]-2-chloroacetamide

(RS)-2-amino-2-(3-bromo-phenyl)-propionic acid methyl ester

rac-5-(3-bromophenyl)-5-methylmorpholin-3-one

Downstream raw materials:

(RS)-[bis-(4-methoxy-phenyl)-phenyl-methyl]-[5-(3-bromo-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-amine

(RS)-[5-(3-amino-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine

{5-[3-(6-bromo-benzo[d]isothiazol-3-ylamino)phenyl]-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl}-carbamic acid tert-butyl ester

[3-(5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-(6-bromo-benzo[d]isothiazol-3-yl)-amine

Refernces

• 1、 -. "NOVEL OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE". . . Retrieved 2013/04/25.
• 2、 -. "1,4 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS". . . Retrieved 2012/07/28.