HT-2 Toxin 3-Glucuronide

Base Information

• Chemical Name: HT-2 Toxin 3-Glucuronide
• CAS No.: 100690-35-5
• Molecular Formula: C28H40O14
• Molecular Weight: 600.617
• Mol file: 100690-35-5.mol

Synonyms:HT-2 Toxin 3-Glucuronide;(3alpha,4beta,8alpha)-15-(Acetyloxy)-12,13-epoxy-4-hydroxy-8-(3-methyl-1-oxobutoxy)trichothec-9-en-3-yl beta-D-glucopyranosiduronic acid

Chemical Property of HT-2 Toxin 3-Glucuronide

Chemical Property:

• PSA: 211.04000
• LogP: -0.96160

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: HT-2 Toxin 3-Glucuronide is an analogue of HT-2 Toxin (H671800) which is a trichothecene group mycotoxin. HT-2 Toxin is the 4-hydroxy analogue of T-2 Toxin (T002980) which has been shown to induce DNA damage and cell death on prolonged administration.

Technology Process of HT-2 Toxin 3-Glucuronide

There total 2 articles about HT-2 Toxin 3-Glucuronide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

T-2 toxin (20181-53-7,21259-20-1,42461-85-8,115589-76-9,118204-87-8) + uridine diphosphoglucuronic acid (2616-64-0,7305-43-3,50722-58-2,106864-00-0,14520-48-0,30329-32-9,3545-73-1,5918-40-1) → 3α-(1''β-D-Glucopyranosiduronyl)-8α-isovaleryloxy-scirpen-3,4β,15-triol 15-acetate (100690-35-5)

Guidance literature:

With magnesium chloride; β-napthoflavone-induced hepatic microsomes from male Long-Evans rats, phosphate buffer;

DOI:10.1016/S0040-4039(00)95002-0

Reference yield:

T-2 toxin (21259-20-1) + UDP-glucuronic acid (1245697-26-0,106864-00-0,14520-48-0,30329-32-9,3545-73-1,5918-40-1) → T-2 toxin 3-β-D-glucuronide (98760-43-1) + HT-2-3-glucuronic acid (100690-35-5) + HT-2-4-glucuronic acid (1400867-48-2) + HT-2 toxin (26934-87-2)

Guidance literature:

With microsomal protein; alamethicin; In aq. buffer; at 37 ℃; for 2h; pH=7.4;

DOI:10.1021/jf302571y

Reference yield:

HT-2-3-glucuronic acid (100690-35-5) → D-glucuronic acid (489-91-8,528-16-5,552-12-5,577-46-8,643-33-4,2240-07-5,6294-16-2,10133-02-5,18402-78-3,18968-14-4,21179-08-8,23018-83-9,33599-45-0,33599-46-1,46171-67-9,46171-69-1,46172-26-3,70021-34-0,71031-08-8,104195-06-4,106499-29-0,124817-72-7) + HT-2 toxin (26934-87-2)

Guidance literature:

With water; β-glucuronidases, type H5 from Helix pomatia; In aq. acetate buffer; at 37 ℃; for 24h; pH=4.5;

DOI:10.1021/jf302571y

upstream raw materials:

T-2 toxin

uridine diphosphoglucuronic acid

T-2 toxin

UDP-glucuronic acid

Downstream raw materials:

D-glucuronic acid

HT-2 toxin

Refernces

• 1、 Welsch, Tanja,Humpf, Hans-Ulrich. "HT-2 toxin 4-glucuronide as new T-2 toxin metabolite: Enzymatic synthesis, analysis, and species specific formation of T-2 and HT-2 toxin glucuronides by rat, mouse, pig, and human liver microsomes". . p. 10170 - 10178,9. Retrieved 2020/09/15.