3-Bromo-2,4-dihxdroxypyridine

Base Information

• Chemical Name: 3-Bromo-2,4-dihxdroxypyridine
• CAS No.: 80791-79-3
• Molecular Formula: C5H4BrNO2
• Molecular Weight: 189.996
• Mol file: 80791-79-3.mol

Synonyms:3-Bromo-2,4-dihxdroxypyridine

Chemical Property of 3-Bromo-2,4-dihxdroxypyridine

Chemical Property:

• Melting Point: 226.5-227.5 °C
• Boiling Point: 268.4±40.0 °C(Predicted)
• PKA: 4.50±1.00(Predicted)
• PSA: 53.35000
• Density: 2.044±0.06 g/cm3(Predicted)
• LogP: 1.25530
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

3-Bromopyridine-2,4-diol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-2,4-dihxdroxypyridine

There total 5 articles about 3-Bromo-2,4-dihxdroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3,5-dibromo-4-hydroxy-2-pyridinone (80791-78-2) → 5-bromo-4-hydroxy-2-pyridinone (80791-79-3)

Guidance literature:

With hydrogen bromide; aniline; In water; at 100 ℃; for 4h;

DOI:10.1139/v81-498

Reference yield:

4-hydroxy-2-pyridone (626-03-9) → 5-bromo-4-hydroxy-2-pyridinone (80791-79-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / Br₂

2: 82 percent / aniline, 47percent HBr / H₂O / 4 h / 100 °C

With hydrogen bromide; bromine; aniline; In water;

DOI:10.1139/v81-498

Reference yield:

3-bromo-2,4-dihydroxypyridine (96245-97-5) → 5-bromo-pyridine-2,4-diol (80791-79-3)

Guidance literature:

With hydrogen bromide; at 200 ℃;

upstream raw materials:

3-bromo-2,4-dihydroxypyridine

3,5-dibromo-2,4-dihydroxypyridine

3,5-dibromo-4-hydroxy-2-pyridinone

4-hydroxy-2-pyridone

Downstream raw materials:

5-bromo-2,4,-dichloropyridine

5-bromo-2,4-dihydroxy-3-nitropyridine

3-chloro-pyridine-2,4-diol

5-bromo-2,4-dichloro-3-nitro-pyridine

Refernces

• 1、 Robins,Kaneko,Kaneko. "Nucleic acid related compounds. 35. Synthesis of 5-bromo- and 5-deuterio-3-deazauridine". . p. 3356 - 3359. Retrieved 2007/10/02.