Ethyl-(R)-piperidin-3-yl-carbaMic acid tert-butyl ester

Base Information

• Chemical Name: Ethyl-(R)-piperidin-3-yl-carbaMic acid tert-butyl ester
• CAS No.: 1196506-95-2
• Molecular Formula: C12H24N2O2
• Molecular Weight: 228.33116
• Hs Code.: 2933399990
• Mol file: 1196506-95-2.mol

Synonyms:Ethyl-(R)-piperidin-3-yl-carbaMic acid tert-butyl ester

Chemical Property of Ethyl-(R)-piperidin-3-yl-carbaMic acid tert-butyl ester

Chemical Property:

• PSA: 41.57000
• LogP: 2.32420
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

(R)-3-[Boc(ethyl)amino]piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl-(R)-piperidin-3-yl-carbaMic acid tert-butyl ester

There total 3 articles about Ethyl-(R)-piperidin-3-yl-carbaMic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-benzyl 3-(tert-butoxycarbonyl(ethyl)amino)piperidine-1-carboxylate (1196506-93-0) → tert-butyl N-ethyl-N-(3-piperidyl)carbamate (1196506-95-2,1184540-14-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; ethanol; for 4h;

Reference yield:

(R)-piperidin-3-ylcarbamic acid tert-butyl ester (309956-78-3,172603-05-3) → tert-butyl N-ethyl-N-(3-piperidyl)carbamate (1196506-95-2,1184540-14-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0 °C / Cooling

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

2.2: 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol; ethanol / 4 h

With hydrogen; sodium hydride; triethylamine; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

(R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester (485820-12-0) → tert-butyl N-ethyl-N-(3-piperidyl)carbamate (1196506-95-2,1184540-14-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

1.2: 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol; ethanol / 4 h

With hydrogen; sodium hydride; palladium 10% on activated carbon; In methanol; ethanol; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

(R)-benzyl 3-(tert-butoxycarbonyl(ethyl)amino)piperidine-1-carboxylate

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

(R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester

Refernces