Technology Process of 4-amino-3-[6-(2-butoxy-3-ethoxy-5-formylphenyl)pyridin-3-ylazo]naphthalene-1-sulfonic acid sodium salt
There total 7 articles about 4-amino-3-[6-(2-butoxy-3-ethoxy-5-formylphenyl)pyridin-3-ylazo]naphthalene-1-sulfonic acid sodium salt which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-(5-aminopyridin-2-yl)-4-butoxy-5-ethoxybenzaldehyde;
With
hydrogenchloride; acetic acid;
In
water;
With
sodium nitrite;
In
water;
at 0 - 5 ℃;
for 0.25h;
4-amino-1-naphthalenesufonic acid;
In
water;
at 5 - 10 ℃;
for 1h;
pH=7 - 10;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -10 °C
1.2: 2 h / -10 °C
2.1: sodium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; Dimethyl ether / 2 h / Inert atmosphere; Reflux
3.1: iron; ammonium chloride / ethanol / 1 h / 75 °C
4.1: hydrogenchloride; acetic acid / water
4.2: 0.25 h / 0 - 5 °C
4.3: 1 h / 5 - 10 °C / pH 7 - 10
With
hydrogenchloride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); isopropylmagnesium chloride; iron; sodium carbonate; ammonium chloride; acetic acid;
In
tetrahydrofuran; ethanol; Dimethyl ether; water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl acetamide / 4 h / 60 °C
2.1: ammonium chloride / ethanol / 4 h / Reflux
3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -10 °C
3.2: 2 h / -10 °C
4.1: sodium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; Dimethyl ether / 2 h / Inert atmosphere; Reflux
5.1: iron; ammonium chloride / ethanol / 1 h / 75 °C
6.1: hydrogenchloride; acetic acid / water
6.2: 0.25 h / 0 - 5 °C
6.3: 1 h / 5 - 10 °C / pH 7 - 10
With
hydrogenchloride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); isopropylmagnesium chloride; iron; sodium carbonate; potassium carbonate; ammonium chloride; acetic acid;
In
tetrahydrofuran; ethanol; Dimethyl ether; N,N-dimethyl acetamide; water;
