3-ETHOXY-4-HYDROXY-5-IODOBENZALDEHYDE

Base Information

• Chemical Name: 3-ETHOXY-4-HYDROXY-5-IODOBENZALDEHYDE
• CAS No.: 6312-82-9
• Molecular Formula: C9H9IO3
• Molecular Weight: 292.073
• Hs Code.: 2913000090
• Mol file: 6312-82-9.mol

Synonyms:3-Ethoxy-4-hydroxy-5-iodobenzaldehyde;5-Iodo-3-ethoxy-4-hydroxybenzaldehyde;NSC 40555;

Chemical Property of 3-ETHOXY-4-HYDROXY-5-IODOBENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.000199mmHg at 25°C
• Refractive Index: 1.649
• Boiling Point: 318 °C at 760mmHg
• Flash Point: 146.1 °C
• PSA: 46.53000
• Density: 1.801 g/cm³
• LogP: 2.20800

Purity/Quality:

99% ^*data from raw suppliers

3-Ethoxy-4-hydroxy-5-iodobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-ETHOXY-4-HYDROXY-5-IODOBENZALDEHYDE

There total 1 articles about 3-ETHOXY-4-HYDROXY-5-IODOBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-hydroxy-3-ethoxybenzaldehyde (121-32-4) → 3-ethoxy-4-hydroxy-5-iodobenzaldehyde (6312-82-9)

Guidance literature:

With iodine; sodium hydrogencarbonate; potassium iodide; In water; at 20 ℃;

DOI:10.1055/s-0036-1591514

Reference yield: 93.0%

4-nitrobenzyl iodide (3145-86-6) + 3-ethoxy-4-hydroxy-5-iodobenzaldehyde (6312-82-9) → 3-ethoxy-5-iodo-4-(4-methylbenzyloxy)benzaldehyde

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.ejmech.2015.08.054

Reference yield: 84.0%

3-ethoxy-4-hydroxy-5-iodobenzaldehyde (6312-82-9) + 1-bromomethyl-4-nitro-benzene (100-11-8) → 3-ethoxy-5-iodo-4-(4-nitrobenzyloxy)benzaldehyde

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2015.08.054

upstream raw materials:

4-hydroxy-3-ethoxybenzaldehyde

Downstream raw materials:

8-Ethoxy-2,2-dimethyl-2H-chromene-6-carbaldehyde

4-amino-3-[6-(2-butoxy-3-ethoxy-5-formylphenyl)pyridin-3-ylazo]naphthalene-1-sulfonic acid sodium salt

2-butoxy-1-ethoxy-5-(diethoxymethyl)-3-iodobenzene

2-butoxy-3-ethoxy-5-formylphenylboronic acid

Refernces

• 1、 Varró, Gábor,Mattyasovszky, Lenke,Grün, Alajos,Simon, András,Hegedüs, László,Kádas, István. "Highly Stereoselective Synthesis of trans -Dihydronarciclasine Analogues". . p. 625 - 643. Retrieved 2017/11/27.
• 2、 -. "SPIRO AZETIDINE ISOXAZOLE DERIVATIVES AND THEIR USE AS SSTR5 ANTAGONISTS". Paragraph 0515. . Retrieved 2014/09/29.