2-(4-methoxyphenyl)-N-methylacetamide

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-N-methylacetamide
• CAS No.: 59907-36-7
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.219
• Mol file: 59907-36-7.mol

Synonyms:2-(4-methoxyphenyl)-N-methylacetamide

Chemical Property of 2-(4-methoxyphenyl)-N-methylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxyphenyl)-N-methylacetamide

There total 7 articles about 2-(4-methoxyphenyl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-Methoxyphenylacetic acid (104-01-8) + N,N'-Dimethylurea (96-31-1) → 2-(4-methoxyphenyl)-N-methylacetamide (59907-36-7)

Guidance literature:

With 1H-imidazole; In octane; at 130 ℃; for 24h; Reagent/catalyst;

DOI:10.1039/d0sc01317j

Reference yield: 57.0%

3-(2,2-difluoroethenyl)anisole (1608-24-8) + methylamine (74-89-5) → 2-(4-methoxyphenyl)-N-methylacetamide (59907-36-7)

Guidance literature:

methylamine; With potassium tert-butylate; In dimethyl sulfoxide; at 90 ℃; for 0.166667h; Inert atmosphere;

3-(2,2-difluoroethenyl)anisole; With water; In dimethyl sulfoxide; at 90 ℃; for 12h; Inert atmosphere;

DOI:10.1039/C8OB02322K

Reference yield:

4-Methoxyphenylacetic acid (104-01-8) + methylamine (74-89-5) → 2-(4-methoxyphenyl)-N-methylacetamide (59907-36-7)

Guidance literature:

4-Methoxyphenylacetic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 0.583333h;

methylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1002/adsc.201900307

upstream raw materials:

methylamine

4-methoxyphenyl-acetic chloride

4-Methoxyphenylacetic acid

4-methoxy-phenyl acetic acid methyl ester

Downstream raw materials:

2-cyano-N-(4-methoxyphenethyl)-N-methylacetamide

2-cyano-2-diazo-N-(4-methoxyphenethyl)-N-methylacetamide

3-hydroxy-4-(4-methoxyphenyl)-1-methyl-1H-pyrrole-2,5-dione

N-methylhomoanisylamine

Refernces

• 1、 Ramesh, Vinay Bapu,Muniraj, Nachimuthu,Prabhu, Kandikere Ramaiah. "Rh(III)-Catalyzed Distal C-H Alkenylation of Weakly Coordinating Acetamides Via Desilylation Pathway". supporting information. p. 3683 - 3688. Retrieved 2019/07/12.
• 2、 Tantray, Mushtaq A.,Khan, Imran,Hamid, Hinna,Alam, Mohammad Sarwar,Dhulap, Abhijeet,Kalam, Abul. "Synthesis of aryl anilinomaleimide based derivatives as glycogen synthase kinase-3β inhibitors with potential role as antidepressant agents". . p. 6109 - 6119. Retrieved 2016/07/16.