2,4-dichloro-6-trifluoromethylphenylacetic acid

Base Information

• Chemical Name: 2,4-dichloro-6-trifluoromethylphenylacetic acid
• CAS No.: 1421620-55-4
• Molecular Formula: C₉H₅Cl₂F₃O₂
• Molecular Weight: 273.039
• Mol file: 1421620-55-4.mol

Synonyms:2,4-dichloro-6-trifluoromethylphenylacetic acid

Chemical Property of 2,4-dichloro-6-trifluoromethylphenylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-dichloro-6-trifluoromethylphenylacetic acid

There total 3 articles about 2,4-dichloro-6-trifluoromethylphenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichloro-6-trifluoromethylphenylacetic acid methyl ester (1421620-38-3) → 2,4-dichloro-6-trifluoromethylphenylacetic acid (1421620-55-4)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 72h;

Reference yield:

3,5-dichloro-2-aminotrifluoromethylbenzene (62593-17-3) → 2,4-dichloro-6-trifluoromethylphenylacetic acid (1421620-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper dichloride; tert.-butylnitrite / acetonitrile / 20 °C

1.2: 5 h / Reflux

1.3: 1 h / Reflux

2.1: lithium hydroxide; water / tetrahydrofuran / 72 h / 20 °C

With tert.-butylnitrite; water; copper dichloride; lithium hydroxide; In tetrahydrofuran; acetonitrile;

Reference yield:

→ 2,4-dichloro-6-trifluoromethylphenylacetic acid (1421620-55-4)

Guidance literature:

With lithium hydroxide; In methanol; water;

upstream raw materials:

2,4-dichloro-6-trifluoromethylphenylacetic acid methyl ester

3,5-dichloro-2-aminotrifluoromethylbenzene

Downstream raw materials:

2,4-dichloro-6-trifluoromethylbenzylamine

Refernces

• 1、 -. "HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS". Page/Page column. . Retrieved 2014/06/24.
• 2、 -. "HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS". Page/Page column 58. . Retrieved 2013/07/31.