2,4-dichloro-6-trifluoromethylphenylacetic acid methyl ester

Base Information

• Chemical Name: 2,4-dichloro-6-trifluoromethylphenylacetic acid methyl ester
• CAS No.: 1421620-38-3
• Molecular Formula: C₁₀H₇Cl₂F₃O₂
• Molecular Weight: 287.066
• Mol file: 1421620-38-3.mol

Synonyms:2,4-dichloro-6-trifluoromethylphenylacetic acid methyl ester

Chemical Property of 2,4-dichloro-6-trifluoromethylphenylacetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-dichloro-6-trifluoromethylphenylacetic acid methyl ester

There total 4 articles about 2,4-dichloro-6-trifluoromethylphenylacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-Dichloroethylene (75-35-4,9002-85-1) + 3,5-dichloro-2-aminotrifluoromethylbenzene (62593-17-3) + sodium methylate (124-41-4) → 2,4-dichloro-6-trifluoromethylphenylacetic acid methyl ester (1421620-38-3)

Guidance literature:

1,1-Dichloroethylene; 3,5-dichloro-2-aminotrifluoromethylbenzene; With tert.-butylnitrite; copper dichloride; In acetonitrile; at 20 ℃;

sodium methylate; In methanol; for 5h; Reflux;

With sulfuric acid; In methanol; for 1h; Reflux;

Reference yield:

methanol (67-56-1) + 1,1-Dichloroethylene (75-35-4,9002-85-1) + 3,5-dichloro-2-aminotrifluoromethylbenzene (62593-17-3) → 2,4-dichloro-6-trifluoromethylphenylacetic acid methyl ester (1421620-38-3)

Guidance literature:

1,1-Dichloroethylene; 3,5-dichloro-2-aminotrifluoromethylbenzene; With tert.-butylnitrite; copper dichloride; In acetonitrile; at 20 ℃;

methanol; With sodium methylate; for 5h; Reflux;

Reference yield:

3,5-dichloro-2-aminotrifluoromethylbenzene (62593-17-3) → 2,4-dichloro-6-trifluoromethylphenylacetic acid methyl ester (1421620-38-3)

Guidance literature:

upstream raw materials:

1,1-Dichloroethylene

3,5-dichloro-2-aminotrifluoromethylbenzene

sodium methylate

methanol

Downstream raw materials:

2,4-dichloro-6-trifluoromethylphenylacetic acid

2,4-dichloro-6-trifluoromethylbenzylamine

Refernces

• 1、 -. "HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS". Page/Page column. . Retrieved 2014/06/24.
• 2、 -. "HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS". Page/Page column 58. . Retrieved 2013/07/31.