Technology Process of 2,4-dichloro-6-trifluoromethylbenzylamine
There total 3 articles about 2,4-dichloro-6-trifluoromethylbenzylamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,4-dichloro-6-trifluoromethylphenylacetic acid;
With
diphenyl phosphoryl azide; triethylamine;
In
toluene;
at 110 ℃;
for 3h;
With
potassium trimethylsilonate;
In
tetrahydrofuran; toluene;
at 0 - 20 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper dichloride; tert.-butylnitrite / acetonitrile / 20 °C
1.2: 5 h / Reflux
1.3: 1 h / Reflux
2.1: lithium hydroxide; water / tetrahydrofuran / 72 h / 20 °C
3.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 110 °C
3.2: 0.5 h / 0 - 20 °C
With
tert.-butylnitrite; diphenyl phosphoryl azide; water; triethylamine; copper dichloride; lithium hydroxide;
In
tetrahydrofuran; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium hydroxide; water / tetrahydrofuran / 72 h / 20 °C
2.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 110 °C
2.2: 0.5 h / 0 - 20 °C
With
diphenyl phosphoryl azide; water; triethylamine; lithium hydroxide;
In
tetrahydrofuran; toluene;
