3-AMINO-PROPIONIC ACID METHYL ESTER

Base Information

• Chemical Name: 3-AMINO-PROPIONIC ACID METHYL ESTER
• CAS No.: 4138-35-6
• Molecular Formula: C4H9NO2
• Molecular Weight: 103.121
• Hs Code.: 2922499990
• Mol file: 4138-35-6.mol

Synonyms:3-Aminopropanoicacid methyl ester;3-Aminopropionic acid methyl ester;Methoxycarbonylethylamine;Methyl 3-aminopropionate;Methyl b-alaninate;

Chemical Property of 3-AMINO-PROPIONIC ACID METHYL ESTER

Chemical Property:

• Melting Point: 103-104 °C
• Boiling Point: 151.8°Cat760mmHg
• PKA: 8.67±0.10(Predicted)
• Flash Point: 26.5°C
• PSA: 52.32000
• Density: 1.013g/cm³
• LogP: 0.20850
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-Aminopropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-AMINO-PROPIONIC ACID METHYL ESTER

There total 23 articles about 3-AMINO-PROPIONIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 3-amino propanoic acid (107-95-9) → methyl 3-aminopropanoate (4138-35-6)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 2h; Product distribution / selectivity; Heating / reflux;

Reference yield: 100.0%

3-benzylamino-propionic acid methyl ester (23574-01-8) → methyl 3-aminopropanoate (4138-35-6)

Guidance literature:

With hydrogen; In methanol; under 760 Torr;

DOI:10.1016/S0040-4039(01)00358-6

Reference yield: 79.0%

methyl 3-nitropropionate (20497-95-4) → methyl 3-aminopropanoate (4138-35-6)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; for 0.166667h; Ambient temperature;

DOI:10.1055/s-1986-31497

upstream raw materials:

diazomethane

3-amino propanoic acid

acrylic acid methyl ester

3-phthalimidopropionitrile

Downstream raw materials:

methyl 3-(4-nitrobenzamido)propanoate

DL-pantothenic acid methyl ester

N-(phenyl)-N'-[(2-methoxycarbonyl)ethyl]thiouree

β-alaninamide

Refernces

• 1、 Bao, Yu,Xu, Qihao,Wang, Lin,Wei, Yunfei,Hu, Baichun,Wang, Jian,Liu, Dan,Zhao, Linxiang,Jing, Yongkui. "Studying Histone Deacetylase Inhibition and Apoptosis Induction of Psammaplin A Monomers with Modified Thiol Group". . p. 39 - 47. Retrieved 2021/01/26.
• 2、 Kitsuwa, Kohei,Nakayama, Atsushi,Okamura, Hironori,Saito, Kai,Shinada, Tetsuro,Yamamoto, Yuki,Yasuno, Yoko. "Stereoselective Syntheses of trans-Anhydromevalonic Acid and trans-Anhydromevalonyl Group-Containing Natural Products". . . Retrieved 2022/03/14.