5-METHOXY-N-METHYL-2-NITROBENZENAMINE

Base Information

• Chemical Name: 5-METHOXY-N-METHYL-2-NITROBENZENAMINE
• CAS No.: 69397-93-9
• Molecular Formula: C8H10 N2 O3
• Molecular Weight: 182.179
• Hs Code.: 2922299090
• Mol file: 69397-93-9.mol

Synonyms:m-Anisidine,N-methyl-6-nitro- (6CI); (5-Methoxy-2-nitrophenyl)methylamine;5-Methoxy-N-methyl-2-nitroaniline; N-Methyl-5-methoxy-2-nitroaniline

Chemical Property of 5-METHOXY-N-METHYL-2-NITROBENZENAMINE

Chemical Property:

• Vapor Pressure: 5.8E-05mmHg at 25°C
• Boiling Point: 346.3°C at 760 mmHg
• Flash Point: 163.3°C
• PSA: 67.08000
• Density: 1.258g/cm³
• LogP: 2.24130
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99.99%HPLC ^*data from raw suppliers

5-Methoxy-N-methyl-2-nitrobenzenamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHOXY-N-METHYL-2-NITROBENZENAMINE

There total 19 articles about 5-METHOXY-N-METHYL-2-NITROBENZENAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-fluoro-4-methoxy-1-nitro-benzene (446-38-8) + methylamine (74-89-5) → N-methyl-5-methoxy-2-nitroaniline (69397-93-9)

Guidance literature:

With potassium carbonate; In dichloromethane; water; at 20 ℃; for 48h;

DOI:10.1039/b713044a

Reference yield: 90.0%

4-chloro-2-methylaminonitrobenzene (35966-84-8) + 5-chloro-2-nitroaniline (1635-61-6) → N-methyl-5-methoxy-2-nitroaniline (69397-93-9)

Guidance literature:

With sodium methylate; dimethyl sulfate; In N-methyl-acetamide; methanol; water;

Reference yield: 90.0%

4-chloro-2-methylaminonitrobenzene (35966-84-8) → N-methyl-5-methoxy-2-nitroaniline (69397-93-9)

Guidance literature:

With sodium methylate; In methanol; DMF (N,N-dimethyl-formamide); at 55 ℃; for 2h;

upstream raw materials:

toluene-4-sulfonic acid-(5-methoxy-N-methyl-2-nitro-anilide)

3-chloro-4-nitroanisole

methylamine

N-(5-methoxy-2-nitrophenyl)-p-toluenesulfonamide

Downstream raw materials:

4-methoxy-N²-methyl-benzene-1,2-diamine; dihydrochloride

5-methoxy-N-methyl-1,2-phenylenediamine

C₂₅H₄₂N₂O₄

C₂₀H₃₂N₂O₄

Refernces

• 1、 -. "Benzimidazole compound and application thereof". Paragraph 0202; 0204; 0205. . Retrieved 2019/01/07.
• 2、 Judkins, Joshua C.,Mahanti, Parag,Hoffman, Jacob B.,Yim, Isaiah,Antebi, Adam,Schroeder, Frank C.. "A photocleavable masked nuclear-receptor ligand enables temporal control of C.elegans development". supporting information. p. 2110 - 2113. Retrieved 2014/03/21.