Ethyl hydrazinoacetate

Base Information

• Chemical Name: Ethyl hydrazinoacetate
• CAS No.: 637-80-9
• Molecular Formula: C4H10 N2 O2
• Molecular Weight: 118.136
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID60980016
• Nikkaji Number: J263.672G
• Wikidata: Q82965799
• Mol file: 637-80-9.mol

Synonyms:ethylhydrazinoacetate

Chemical Property of Ethyl hydrazinoacetate

Chemical Property:

• Vapor Pressure: 0.000172mmHg at 25°C
• Melting Point: 152 °C
• Boiling Point: 306.7°C at 760 mmHg
• PKA: 6.07±0.10(Predicted)
• Flash Point: 139.3°C
• PSA: 64.35000
• Density: 1.068±0.06 g/cm3(Predicted)
• LogP: 0.10400
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 118.074227566
• Heavy Atom Count: 8
• Complexity: 74.4

Purity/Quality:

99% ^*data from raw suppliers

Ethyl hydrazinoacetate hydrochloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CNN

Technology Process of Ethyl hydrazinoacetate

There total 3 articles about Ethyl hydrazinoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(diphenylmethylene)-3-oxo-1,2-diazetidinium hydroxide, inner salt (20958-76-3) + ethanol (64-17-5) → benzophenone (119-61-9) + ethyl 2-hydrazinylacetate (637-80-9)

Guidance literature:

With hydrogenchloride; for 3h; Heating;

DOI:10.1021/ja00416a009

Reference yield:

diazoacetic acid ethyl ester (623-73-4) → ethyl 2-hydrazinylacetate (637-80-9)

Guidance literature:

Multistep reaction; (i) aq. NaOH, (ii) Na-Hg;

DOI:10.1002/hlca.19700530517

Reference yield:

ethanol (64-17-5) + chloroacetic acid (79-11-8) → ethyl 2-hydrazinylacetate (637-80-9)

Guidance literature:

Multistep reaction; (i) aq. Na₂CO₃, N₂H₄*H₂O, (ii) /BRN= 1718733/, HCl;

upstream raw materials:

diazoacetic acid ethyl ester

ethanol

chloroacetic acid

1-(diphenylmethylene)-3-oxo-1,2-diazetidinium hydroxide, inner salt

Downstream raw materials:

diazoacetic acid ethyl ester

2-(N-Benzyloxycarbonyl-L-alanyl)-hydrazinoessigsaeure

Benzyloxycarbonyl-(+/-)-seryl-hydrazino-essigsaeure-ethylester

N^α-Benzyloxycarbonyl-hydrazinoessigsaeure-ethylester

Refernces