2,2'-DICHLOROBENZOPHENONE

Base Information

• Chemical Name: 2,2'-DICHLOROBENZOPHENONE
• CAS No.: 5293-97-0
• Molecular Formula: C13H8Cl2O
• Molecular Weight: 251.112
• Hs Code.: 2914700090
• Mol file: 5293-97-0.mol

Synonyms:Benzophenone,2,2'-dichloro- (6CI,7CI,8CI);2,2'-Dichlorobenzophenone;NSC 405580;o,o'-Dichlorobenzophenone;

Chemical Property of 2,2'-DICHLOROBENZOPHENONE

Chemical Property:

• Melting Point: 52-53 °C
• Boiling Point: 364.8 °C at 760 mmHg
• Flash Point: 154.2 °C
• PSA: 17.07000
• Density: 1.311 g/cm³
• LogP: 4.22440

Purity/Quality:

99% ^*data from raw suppliers

bis(2-Chlorophenyl)methanone ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2'-DICHLOROBENZOPHENONE

There total 13 articles about 2,2'-DICHLOROBENZOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

carbon monoxide (201230-82-2) + 2-Chlorobenzeneboronic acid (3900-89-8) → 2,2'-dichlorobenzophenone (5293-97-0)

Guidance literature:

With oxygen; palladium diacetate; potassium hydrogencarbonate; sodium iodide; at 80 ℃; for 22h; under 760.051 Torr;

DOI:10.1002/ejoc.201600689

Reference yield: 70.0%

2,2'-dichloro-benzhydrol (6335-15-5) → 2,2'-dichlorobenzophenone (5293-97-0)

Guidance literature:

With zinc(II) chlorosulphate; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1055/s-1992-26288

Reference yield: 66.0%

→ 2,2'-dichlorobenzophenone (5293-97-0)

Guidance literature:

With copper(l) iodide; 5% Pd-CaCO3; In dimethyl sulfoxide; at 50 ℃; for 12h; under 114.008 - 1406.09 Torr;

upstream raw materials:

1,1'-methylenebis(2-chlorobenzene)

α-(hydroxy)-2-chloro-α-(2-chlorophenyl)benzeneacetic acid

2,2'-dichloro-benzhydrol

o-chlorobenzoyl chloride

Downstream raw materials:

C₁₅H₁₄Cl₂O₂

thio-xanthene-9-one

2,2'-bis(methylthio)benzophenone

2,2-bis(2-chlorophenyl)ethanol

Refernces

• 1、 -. "Method for preparing symmetric diarylketone through catalytic oxidative carbonylation". Paragraph 0023; 0024; 0025; 0026; 0029. . Retrieved 2019/03/08.
• 2、 Li, Yang,Lu, Wei,Xue, Dong,Wang, Chao,Liu, Zhao-Tie,Xiao, Jianliang. "Palladium-catalyzed oxidative carbonylation for the synthesis of symmetrical diaryl ketones at atmospheric co pressure". supporting information. p. 1097 - 1100. Retrieved 2014/05/20.