Technology Process of (αR, βS)-α-hydroxy-β-[[(1,1-dimethylethoxy)carbonyl]amino]benzene-propanoic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,1112,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester isopropanol solvate
There total 12 articles about (αR, βS)-α-hydroxy-β-[[(1,1-dimethylethoxy)carbonyl]amino]benzene-propanoic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,1112,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester isopropanol solvate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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![(αR, βS)-α-hydroxy-β-[[(1,1-dimethylethoxy)carbonyl]amino]benzene-propanoic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,1112,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester isopropanol solvate](/Databaselist/images/loading.webp)
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1402820-62-5
(αR, βS)-α-hydroxy-β-[[(1,1-dimethylethoxy)carbonyl]amino]benzene-propanoic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,1112,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester isopropanol solvate
- Guidance literature:
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carbazitaxel;
With
hydrogenchloride;
In
methanol; water;
at 20 - 30 ℃;
isopropyl alcohol;
In
dichloromethane;
at 0 - 30 ℃;
for 3.5h;
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1402820-62-5
(αR, βS)-α-hydroxy-β-[[(1,1-dimethylethoxy)carbonyl]amino]benzene-propanoic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,1112,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester isopropanol solvate
- Guidance literature:
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Multi-step reaction with 7 steps
1.1: 1H-imidazole / dichloromethane / 0 - 20 °C
2.1: sodium hydride / N,N-dimethyl acetamide / -15 - -5 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 25 °C
4.1: sodium hydride / N,N-dimethyl acetamide / 1 h / -15 - -5 °C
5.1: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C
6.1: hydrogenchloride / ethyl acetate / 0 °C
7.1: hydrogenchloride / methanol; water / 20 - 30 °C
7.2: 3.5 h / 0 - 30 °C
With
1H-imidazole; hydrogenchloride; dmap; tetrabutyl ammonium fluoride; sodium hydride;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water; ethyl acetate;
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1402820-62-5
(αR, βS)-α-hydroxy-β-[[(1,1-dimethylethoxy)carbonyl]amino]benzene-propanoic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,1112,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester isopropanol solvate
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C
2.1: hydrogenchloride / ethyl acetate / 0 °C
3.1: hydrogenchloride / methanol; water / 20 - 30 °C
3.2: 3.5 h / 0 - 30 °C
With
hydrogenchloride; dmap;
In
tetrahydrofuran; methanol; water; ethyl acetate;
