Naphazoline

Base Information

• Chemical Name: Naphazoline
• CAS No.: 835-31-4
• Molecular Formula: C14H15ClN2
• Molecular Weight: 210.279
• Hs Code.: 2934999090
• European Community (EC) Number: 212-641-5,233-197-9
• UNII: H231GF11BV
• DSSTox Substance ID: DTXSID3048449
• Nikkaji Number: J7.133A
• Wikipedia: Naphazoline
• Wikidata: Q415433
• NCI Thesaurus Code: C61856
• RXCUI: 7247
• Pharos Ligand ID: XAY4X48XV6AY
• Metabolomics Workbench ID: 43690
• ChEMBL ID: CHEMBL761
• Mol file: 835-31-4.mol

Synonyms:Afazol Grin;AK Con;AK-Con;Albalon;All Clear;Clear Eyes;Colirio Alfa;Hydrochloride, Naphazoline;Idril;Miraclar;Monohydrochloride, Naphazoline;Nafazair;Naphazoline;Naphazoline Hydrochloride;Naphazoline Monohydrochloride;Naphazoline Nitrate;Naphcon;Naphcon forte;Nitrate, Naphazoline;Optazine;Pensa, Vasoconstrictor;Privin;Privine;Proculin;Siozwo;Tele Stulln;Tele-Stulln;Vasoclear;Vasocon;Vasocon Regular;Vasoconstrictor Pensa;VasoNit

Chemical Property of Naphazoline

Chemical Property:

• Vapor Pressure: 1.52E-07mmHg at 25°C
• Melting Point: 254 °C
• Refractive Index: 1.64
• Boiling Point: 440.466 °C at 760 mmHg
• PKA: pKa 10.35 ± 0.02(H2O,t =25,Iundefined) (Uncertain)
• Flash Point: 220.186 °C
• PSA: 24.39000
• Density: 1.156 g/cm³
• LogP: 2.14840
• Storage Temp.: 2-8°C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 210.115698455
• Heavy Atom Count: 16
• Complexity: 272

Purity/Quality:

99%min ^*data from raw suppliers

Naphazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN=C(N1)CC2=CC=CC3=CC=CC=C32
• Recent ClinicalTrials: Evaluation of SAR408701 in Japanese Patients With Advanced Malignant Solid Tumors
• Recent EU Clinical Trials: Patient-controlled sedation with propofol versus combined sedation during bronchoscopy – a randomized controlled trial
• Uses: Naphazoline is used in severe rhinitis associated with colds, allergic reactions, and severe and chronic inflammatory conditions, in particular for inflammation of the antrum of Highmore as well as for stopping nosebleeds.

Technology Process of Naphazoline

There total 10 articles about Naphazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

naphth-1-yl acetic acid (86-87-3) + ethylenediamine (107-15-3,85404-18-8) → naphazoline (835-31-4)

Guidance literature:

for 2h; Time; Reflux;

Reference yield:

naphthalen-1-ylacetonitrile (132-75-2) + ethylenediamine (107-15-3,85404-18-8) → naphazoline (835-31-4)

Guidance literature:

With carbon disulfide; at 110 ℃; for 2h; Reagent/catalyst; Temperature;

Reference yield:

N-[1]naphthylacetyl-glycine nitrile → naphazoline (835-31-4)

Guidance literature:

With ammonia; nickel; isopropyl alcohol; at 70 ℃; under 73550.8 Torr; Hydrogenation_.Erhitzen des Reaktionsprodukts unter vermindertem Druck;

upstream raw materials:

naphthalen-1-ylacetonitrile

ethylene diamine mono-p-toluenesulfonic acid salt

naphth-1-yl acetic acid

1,2-ethanediamine monohydrate

Downstream raw materials:

naphazoline hydrochloride

N-(1-naphthylacetyl)ethylenediamine

Refernces

• 1、 -. "Preparation method of naphazoline hydrochloride". Paragraph 0040-0042; 0045-0047; 0050-0052; 0055-0057. . Retrieved 2019/08/03.
• 2、 -. "Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives". Page/Page column 43; 48. . Retrieved 2010/11/28.