l-nicotine di-(p-toluoyl)-d-tartrate

Base Information

• Chemical Name: l-nicotine di-(p-toluoyl)-d-tartrate
• CAS No.: 68935-25-1
• Molecular Formula: C₁₀H₁₄N₂*C₂₀H₁₈O₈
• Molecular Weight: 548.593
• Mol file: 68935-25-1.mol

Synonyms:l-nicotine di-(p-toluoyl)-d-tartrate

Chemical Property of l-nicotine di-(p-toluoyl)-d-tartrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of l-nicotine di-(p-toluoyl)-d-tartrate

There total 6 articles about l-nicotine di-(p-toluoyl)-d-tartrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.1%

(2S,3S)-di-4-toluoyltartaric acid (32634-68-7) + 3-(1-methyl-pyrrolidin-2-yl)-pyridine (22083-74-5) → l-nicotine di-(p-toluoyl)-d-tartrate (68935-25-1)

Guidance literature:

In methanol; isopropyl alcohol; at 20 ℃; for 2.25h; Reflux;

Reference yield:

(2S,3S)-di-4-toluoyltartaric acid (32634-68-7) + 3-(1-methyl-pyrrolidin-2-yl)-pyridine (22083-74-5) → nicotine di-p-toluoyl tartrate (68935-27-3) + l-nicotine di-(p-toluoyl)-d-tartrate (68935-25-1)

Guidance literature:

In ethanol; Reflux;

Reference yield:

nicotin (54-11-5) → l-nicotine di-(p-toluoyl)-d-tartrate (68935-25-1)

Guidance literature:

Multi-step reaction with 2 steps

1: KH / xylene / 1 h / Heating; other reagent, solvent, reaction time

2: ethanol

With potassium hydride; In ethanol; xylene;

upstream raw materials:

(2S,3S)-di-4-toluoyltartaric acid

3-(1-methyl-pyrrolidin-2-yl)-pyridine

nicotin

D-nicotine

Refernces

• 1、 -. "PROCESS FOR THE RESOLUTION OF (R,S)-NICOTINE". Page/Page column 3. . Retrieved 2012/08/08.
• 2、 Bowman, Edward R.,McKennis, Herbert,Martin, Billy R.. "A CONVENIENT METHOD FOR THE PREPARATION OF RACEMIC NICOTINE". . p. 871 - 880. Retrieved 2007/10/02.