SODIUM METHYLENEDIPHOSPHONATE

Base Information

• Chemical Name: SODIUM METHYLENEDIPHOSPHONATE
• CAS No.: 6145-29-5
• Molecular Formula: CH₃O₆P₂*3Na
• Molecular Weight: 241.948
• Mol file: 6145-29-5.mol

Synonyms:

Chemical Property of SODIUM METHYLENEDIPHOSPHONATE

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of SODIUM METHYLENEDIPHOSPHONATE

There total 3 articles about SODIUM METHYLENEDIPHOSPHONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C5H6NO9P2(5-)*5Na(1+) → Methylendiphosphoniumsaeure-tetranatriumsalz (6145-29-5,17721-67-4,25681-89-4,29329-67-7,39478-93-8) + C4H5NO4(2-)*2Na(1+)

Guidance literature:

With water; carbamoyl phosphate; In various solvent(s); at 37 ℃; for 0.166667h; pH=8.0; Further Variations:; Reagents; Temperatures; Product distribution;

DOI:10.1016/j.ejmech.2004.01.006

Reference yield:

Tetraisopropyl methylenediphosphonate (1660-95-3) → Methylendiphosphoniumsaeure-tetranatriumsalz (6145-29-5,17721-67-4,25681-89-4,29329-67-7,39478-93-8)

Guidance literature:

With trimethylsilyl bromide; Dowex 50; Yield given. Multistep reaction; 1.) r.t., 20 h, 2.) water;

DOI:10.1016/0022-328X(85)80161-3

Reference yield:

trimethylsilyl bromide (2857-97-8) + Tetraethyl methylenediphosphonate (1660-94-2) → methanediphosphonic acid trisodium salt (6145-29-5,17721-67-4,25681-89-4,29329-67-7,39478-93-8) + CH2(2)HO6P2(3-)*3Na(1+) (143521-77-1) + CH(2)H2O6P2(3-)*3Na(1+) (143521-78-2)

Guidance literature:

Yield given. Multistep reaction. Title compound not separated from byproducts;

DOI:10.1016/S0040-4039(00)74821-0

upstream raw materials:

Tetraisopropyl methylenediphosphonate

trimethylsilyl bromide

Tetraethyl methylenediphosphonate

Downstream raw materials:

α-D-glucopyranosyl-1-phosphate

Refernces

• 1、 Blackburn,Rosenberg,Yakovleva. "Synthesis and heteronuclear NMR analysis of deuterium- and tritium-labelled methylenebisphosphonic acid". . p. 3927 - 3930. Retrieved 2007/10/02.