(RS)-N-(1-phenylethyl)-P,P-diphenylphosphinamide

Base Information

• Chemical Name: (RS)-N-(1-phenylethyl)-P,P-diphenylphosphinamide
• CAS No.: 67764-56-1
• Molecular Formula: C₂₀H₂₀NOP
• Molecular Weight: 321.359
• Mol file: 67764-56-1.mol

Synonyms:(RS)-N-(1-phenylethyl)-P,P-diphenylphosphinamide

Chemical Property of (RS)-N-(1-phenylethyl)-P,P-diphenylphosphinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (RS)-N-(1-phenylethyl)-P,P-diphenylphosphinamide

There total 17 articles about (RS)-N-(1-phenylethyl)-P,P-diphenylphosphinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-Phenylethanol (98-85-1,13323-81-4) + diphenylphosphinamide (5994-87-6) → (RS)-N-(1-phenylethyl)-P,P-diphenylphosphinamide (67764-56-1)

Guidance literature:

With carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)-amino]ruthenium(II); potassium hydroxide; In toluene; at 140 ℃; for 16h; Inert atmosphere; Sealed tube; Glovebox;

DOI:10.1016/j.tet.2019.04.029

Reference yield: 88.0%

methyllithium (917-54-4) + N-benzylidenediphenylphosphinamide (98837-46-8) → (RS)-N-(1-phenylethyl)-P,P-diphenylphosphinamide (67764-56-1)

Guidance literature:

With chiral dimethoxydiphenylethane; In toluene; at -78 ℃;

Reference yield: 85.0%

dimethyl zinc(II) (544-97-8) + N-benzylidenediphenylphosphinamide (98837-46-8) → (RS)-N-(1-phenylethyl)-P,P-diphenylphosphinamide (67764-56-1)

Guidance literature:

bis(acetylacetonate)nickel(II); In toluene; acetonitrile; at 0 ℃; for 1h;

DOI:10.1016/j.tet.2006.11.056

upstream raw materials:

rac-methylbenzylamine

Diphenylphosphinic chloride

P,P-diphenyl-N-(1-phenylethylidene)phosphinic amide

methyl magnesium iodide

Downstream raw materials:

diphenyl-phosphinic acid

rac-methylbenzylamine

rac-N-methyl-P,P-diphenyl-N-(1-phenylethyl)phosphinic amide

(α)-methylbenzylamine hydrochloride

Refernces

• 1、 Seo, Chris S. G.,Tannoux, Thibault,Smith, Samantha A. M.,Lough, Alan J.,Morris, Robert H.. "Enantioselective Hydrogenation of Activated Aryl Imines Catalyzed by an Iron(II) P-NH-P′ Complex". . p. 12040 - 12049. Retrieved 2019/10/02.
• 2、 Xiao, Jing,Li, Ping,Zhang, Yingjun,Xie, Dexun,Peng, Zhihong,An, Delie,Dong, Wanrong. "Cobalt-catalyzed oxidative arylmethylation of phosphorylamides". . p. 4558 - 4568. Retrieved 2018/07/30.