2,3-benzo-10-benzyl-10-aza-1,4,7,13-tetraoxa-2-cyclopentadecene

Base Information

• Chemical Name: 2,3-benzo-10-benzyl-10-aza-1,4,7,13-tetraoxa-2-cyclopentadecene
• CAS No.: 107102-14-7
• Molecular Formula: C₂₁H₂₇NO₄
• Molecular Weight: 357.45
• Mol file: 107102-14-7.mol

Synonyms:2,3-benzo-10-benzyl-10-aza-1,4,7,13-tetraoxa-2-cyclopentadecene

Chemical Property of 2,3-benzo-10-benzyl-10-aza-1,4,7,13-tetraoxa-2-cyclopentadecene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-benzo-10-benzyl-10-aza-1,4,7,13-tetraoxa-2-cyclopentadecene

There total 3 articles about 2,3-benzo-10-benzyl-10-aza-1,4,7,13-tetraoxa-2-cyclopentadecene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

bis(o-phenylene)glycol ditosylate (54535-06-7) + N-benzyl-diethanolamine (101-32-6) → 2,3-benzo-10-benzyl-10-aza-1,4,7,13-tetraoxa-2-cyclopentadecene (107102-14-7)

Guidance literature:

With tetrabutylammomium bromide; sodium hydroxide; In water; benzene; at 70 ℃; for 7h; Reagent/catalyst;

DOI:10.1134/S1070428012100156

Reference yield:

2,2'-(1,2-phenylenedioxy)diethanol (10234-40-9) → 2,3-benzo-10-benzyl-10-aza-1,4,7,13-tetraoxa-2-cyclopentadecene (107102-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / sodium hydroxide / H₂O; tetrahydrofuran / 3 h / 0 °C

2: 32 percent / sodium hydride / tetrahydrofuran / 45 h / Heating

With sodium hydroxide; sodium hydride; In tetrahydrofuran; water;

DOI:10.1021/jo0107148

Reference yield:

benzyl chloride (100-44-7) → 2,3-benzo-10-benzyl-10-aza-1,4,7,13-tetraoxa-2-cyclopentadecene (107102-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / sodium carbonate / acetonitrile / 9 h / Heating

2: 32 percent / sodium hydride / tetrahydrofuran / 45 h / Heating

With sodium hydride; sodium carbonate; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jo0107148

upstream raw materials:

bis(o-phenylene)glycol ditosylate

N-benzyl-diethanolamine

2,2'-(1,2-phenylenedioxy)diethanol

benzyl chloride

Downstream raw materials:

benzo-10-aza-15-crown-5

4'-formyl-2,3-benzo-10-benzyl-10-aza-1,4,7,13-tetraoxa-2-cyclopentadecene

Refernces

• 1、 Nakamura, Mitsunobu,Yokono, Hideaki,Tomita, Ken-Ichi,Ouchi, Mikio,Miki, Masamichi,Dohno, Reizo. "Substitution effect, absorption, and fluorescence behaviors of 11,12-benzo-1,7,10,13-tetraoxa-4-azacyclopentadec-11-ene (Benzoaza-15-crown-5) derivatives upon cation complexation in solvent extraction". . p. 3533 - 3536. Retrieved 2007/10/03.